Anti-arthritic activity of solvent extracts of the bulbs of Crinum pedunculatum R.Br.

Q4 Pharmacology, Toxicology and Pharmaceutics

Pharmaceutical Sciences Asia Pub Date : 2022-01-01 DOI:10.29090/psa.2022.06.22.138

P. Doe, C. Danquah, P. Ossei, K. Ohemeng, Michael Ofori, Selase Ativui, Yakubu Jibira

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引用次数: 0

Abstract

anti-inflammatory drugs (NSAIDS) which have various side effects ABSTRACT Crinum pedunculatum (R.Br) has been used by traditional medicine practitioners in Ghana for the topical management of inflammation and associated disorders. This study investigated the anti-arthritic activity of the methanol, ethanol and ethyl acetate extract of the bulbs of Crinum pedunculatum using Sprague Dawley rats. The anti-arthritic activity of Crinum pedunculatum at various doses (100, 200 and 400 mg/kg) was evaluated using Complete Freund’s Adjuvant (CFA) in rat model. After successful induction of the arthritis, the paw oedema, hematological parameters, pro-inflammatory cytokines and arthritis marker were assessed. Also, the radiological and histopathological evaluations were also performed. There was a significant inhibition ( P <0.01) of paw oedema after treatment with 100, 200 and 400 mg/kg of the methanol, ethanol and ethyl acetate Crinum pedunculatum extracts relative to the control. There was also a significant increase in haemoglobin and RBC levels as well as a decrease in WBC count. All the extracts of Crinum pedunculatum decreased IL-6 and Rheumatoid factor serum concentrations and improved joint and cartilage destruction in both contralateral and ipsilateral paw of CFA-induced rats. Significant anti-arthritic activity was observed by the 200 and 400 mg/kg ethanol and methanol Crinum pedunculatum extract. This study confirms that the bulb of Crinum pedunculatum has an anti-arthritic potential and the findings justify the folkloric use the plant as an anti-inflammatory agent.

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花楸球茎溶剂提取物抗关节炎活性的研究。

【摘要】在加纳，criinum pedunculatum (R.Br)已被传统医学从业者用于炎症和相关疾病的局部治疗。以大鼠为实验对象，研究了长柄荆球茎甲醇、乙醇和乙酸乙酯提取物的抗关节炎活性。采用完全弗氏佐剂法(CFA)对不同剂量(100、200、400 mg/kg)的长柄荆的抗关节炎活性进行大鼠模型评价。成功诱导关节炎后，评估足跖水肿、血液学指标、促炎因子及关节炎标志物。同时进行影像学和组织病理学检查。甲醇、乙醇和乙酸乙酯含量分别为100、200和400 mg/kg的荆芥提取物对足跖水肿的抑制作用较对照组显著(P <0.01)。血红蛋白和红细胞水平也显著增加，白细胞计数也显著减少。所有提取物均可降低血清IL-6和类风湿因子浓度，改善对侧和同侧足跖关节和软骨损伤。200、400 mg/kg乙醇和甲醇提取物均具有显著的抗关节炎活性。本研究证实，长柄海百合的球茎具有抗关节炎的潜力，这一发现证明了民间使用该植物作为抗炎剂的合理性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pharmaceutical Sciences Asia Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)

CiteScore

0.90

自引率

0.00%

发文量

期刊介绍： The Pharmaceutical Sciences Asia (PSA) journal is a double-blinded peer-reviewed journal in English published quarterly, by the Faculty of Pharmacy, Mahidol University, Thailand. The PSA journal is formerly known as Mahidol University Journal of Pharmaceutical Sciences and committed to the timely publication of innovative articles and reviews. This journal is available in both printed and electronic formats. The PSA journal aims at establishing a publishing house that is open to all. It aims to disseminate knowledge; provide a learned reference in the field; and establish channels of communication between academic and research expert, policy makers and executives in industry and investment institutions. The journal publishes research articles, review articles, and scientific commentaries on all aspects of the pharmaceutical sciences and multidisciplinary field in health professions and medicine. More specifically, the journal publishes research on all areas of pharmaceutical sciences and related disciplines: Clinical Pharmacy Drug Synthesis and Discovery Targeted-Drug Delivery Pharmaceutics Biopharmaceutical Sciences Phytopharmaceutical Sciences Pharmacology and Toxicology Pharmaceutical Chemistry Nutraceuticals and Functional Foods Natural Products Social, Economic, and Administrative Pharmacy Clinical Drug Evaluation and Drug Policy Making Antimicrobials, Resistance and Infection Control Pharmacokinetics and Pharmacodynamics.