Maternal consumption of sucrose during lactation may program metabolic dysfunction in young offspring

Nkiru A. Katchy, P. Okeke, E. Iyare
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Abstract

Background: It is well established that the consumption of sugars by both young and old, males and females, has tremendously increased over the past decades. This increased consumption is without prejudice to the physiological state of the body. There is evidence to suggest a correlation between the excessive consumption of these sugars and their adverse metabolic effects. Aim: The aim of this study was carried out to investigate the effect of maternal consumption of sucrose during lactation on some metabolic indices in young offspring of the rat. Methods: Fourteen female albino Wistar rats weighing were used for this study and were randomly assigned into two groups (sucrose group and control group) at delivery. Water and 30% (w/v) sucrose solutions from plastic bottles were made with tap water and administered during lactation until weaning. At postnatal day 42, offspring of sucrose-fed rats showed a statistically significant decrease (P < 0.05) in body weight and food intake when compared with control. The female offspring showed a statistically significant increase (P < 0.05) in liver weight index, total cholesterol, and triglycerides and a significant decrease in high-density lipoprotein (HDL) and insulin values (P < 0.05) when compared with control. The male offspring showed a statistically significant increase (P < 0.05) in the oral glucose tolerance test, total cholesterol, triglycerides, low-density lipoprotein values and a significant decrease in pancreatic weight, HDL, and insulin concentration when compared with control. Conclusion: This study suggests that maternal consumption of sucrose during lactation may contribute to the onset of metabolic dysfunction in the young adult offspring.
母亲在哺乳期摄入蔗糖可能导致幼仔代谢功能障碍
背景:众所周知,在过去的几十年里,无论是年轻人还是老年人,男性还是女性,糖的摄入量都急剧增加。这种增加的消耗并不影响身体的生理状态。有证据表明,过量摄入这些糖与其不利的代谢影响之间存在关联。目的:探讨哺乳期母体蔗糖摄取量对大鼠幼仔某些代谢指标的影响。方法:选用称重的雌性白化Wistar大鼠14只,在分娩时随机分为蔗糖组和对照组。用自来水配制塑料瓶中的水和30% (w/v)蔗糖溶液,在哺乳期至断奶期间给予。出生后第42天,蔗糖喂养大鼠的子代体重和摄食量与对照组相比均有显著降低(P < 0.05)。与对照组相比,雌性子代肝脏重量指数、总胆固醇、甘油三酯均显著升高(P < 0.05),高密度脂蛋白(HDL)、胰岛素值显著降低(P < 0.05)。与对照组相比,雄性后代的口服糖耐量试验、总胆固醇、甘油三酯、低密度脂蛋白值均有统计学意义(P < 0.05)升高,胰腺重量、高密度脂蛋白、胰岛素浓度显著降低。结论:本研究提示,哺乳期母体摄入蔗糖可能会导致幼龄成年后代出现代谢功能障碍。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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