Evaluation of Clinicopathologic Factors and Surgery Management on Borderline Ovarian Tumor Outcomes

IF 0.4 Q4 ONCOLOGY

International Journal of Cancer Management Pub Date : 2022-10-16 DOI:10.5812/ijcm-114910

Z. Shiravani, N. Namazi, Masooumeh Hashemi, Fatemesadat Najib, Mojgan Hajisafari Tafti

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引用次数: 0

Abstract

Background: Borderline ovarian tumor (BOT) is a tumor most prevalent in young woman with desire to fertility. There are some controversies on the patient characteristic besides to the factors affecting the recurrence rate among different races. Objectives: The aim of this study is to evaluate clinicopathologic features of the tumor to discover the controversies on the topic. Methods: Medical data of the all referred patients to Motahari clinic from January 2010 till October 2020 were recorded. Patient clinicopathologic characteristics affecting on outcome were evaluated. By using SPSS software, data were tested by chi-square and fish exact test. Also, log rank test was used for survival analysis Results: Totally 145 patients were enrolled. 61.4% versus 38.6% of the patients underwent fertility sparing surgery and radical surgery respectively with common characteristics of mostly belong to stage 1A disease (61.8% vs. 66.1%), unilateral (93.3% vs. 89.3%), serous histology (51.7% vs. 66.1%). The characteristics were different in the aspects of age and tumor size. In the aspect of recurrence rate, higher FIGO stage, younger age, tumor size less than 10cm, performing laparoscopy and fertility sparing surgery were with higher rate of recurrence (P-value < 0.05) while histology type of the tumor, lateralization, micropapillary, microinvasion, noninvasive peritoneal implants, receiving adjuvant chemotherapy and performing lymphadenectomy were not statistically significant for recurrence (P-value > 0.05). Two patients had malignant transformation. Conclusions: Fertility sparing surgery and higher FIGO stages are with more recurrence rate in Borderline ovarian tumor patients. However, micropapillary, microinvasion were not significantly with higher recurrence rate in our study but they are challenging issues in border line ovarian tumors among different studies. Due to most prevalence of border line ovarian tumors in young women and desire of fertility preservation, we should notice more to clinicopathologic and surgery types affecting on recurrence of BOTs.

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影响卵巢交界性肿瘤预后的临床病理因素及手术处理

背景:交界性卵巢肿瘤(BOT)是一种多见于渴望生育的年轻女性的肿瘤。不同人种间除复发率的影响因素外，对患者的特点也存在争议。目的:本研究的目的是评估肿瘤的临床病理特征，以发现该主题的争议。方法:记录2010年1月至2020年10月Motahari诊所转诊患者的医疗资料。评估患者临床病理特征对预后的影响。采用SPSS软件对数据进行卡方检验和fish精确检验。采用log rank检验进行生存分析结果:共纳入145例患者。分别有61.4%对38.6%的患者行保留生育能力手术和根治性手术，其共同特征主要为1A期(61.8%对66.1%)、单侧(93.3%对89.3%)、浆液组织学(51.7%对66.1%)。其特点在年龄和肿瘤大小方面有所不同。在复发率方面，FIGO分期越高、年龄越小、肿瘤大小小于10cm、行腹腔镜手术及保留生育能力手术复发率越高(p值< 0.05)，而肿瘤组织学类型、偏侧、微乳头状、微侵袭、无创腹膜植入、辅助化疗及行淋巴结切除术对复发率的影响无统计学意义(p值> 0.05)。2例发生恶性转化。结论:保留生育能力手术及FIGO分期较高的交界性卵巢肿瘤患者复发率较高。然而，微乳头状、微侵袭性在我们的研究中并没有明显的高复发率，但在不同的研究中，它们是卵巢边界系肿瘤的一个具有挑战性的问题。由于边界卵巢肿瘤多见于年轻女性，且希望保留生育能力，我们应更多地关注临床病理和手术类型对bot复发的影响。

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来源期刊

International Journal of Cancer Management ONCOLOGY-

CiteScore

1.10

自引率

0.00%

发文量

期刊介绍： International Journal of Cancer Management (IJCM) publishes peer-reviewed original studies and reviews on cancer etiology, epidemiology and risk factors, novel approach to cancer management including prevention, diagnosis, surgery, radiotherapy, medical oncology, and issues regarding cancer survivorship and palliative care. The scope spans the spectrum of cancer research from the laboratory to the clinic, with special emphasis on translational cancer research that bridge the laboratory and clinic. We also consider original case reports that expand clinical cancer knowledge and convey important best practice messages.