Investigation of Formalin-Fixed Tissue Optical Characteristics in the Range of 200–500 GHz Using Pulsed Terahertz Reflection Spectroscopy to Differentiate Oral Malignant, Benign, and Cyst

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2022-02-27 DOI:10.1155/2022/3627705

S. S. Jenifer Isabella, K. Sunitha, K. T. Magesh, S. Arjunan, B. Pesala

引用次数: 2

Abstract

The application of Terahertz electromagnetic waves to diagnose oral cancer was investigated. A single case of formalin-fixed oral squamous cell carcinoma (malignant), ameloblastoma (benign), and odontogenic keratocyst was examined using terahertz pulsed spectroscopy in the frequency span of 0.1–2 THz. The measured absorption coefficient, refractive index, and the extinction coefficient were reported to be high for malignant samples than benign and cyst. The THz results are validated with hematoxylin and eosin-stained microscopic images. The results demonstrate that the THz signal was shown to be consistently higher for the malignant sample compared to benign and the cyst. These results indicate that THz signals responded to the cell density by eliminating the effect of water.

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使用脉冲太赫兹反射光谱研究200-500 GHz范围内福尔马林固定组织的光学特性以鉴别口腔恶性、良性和囊肿

研究了太赫兹电磁波在口腔癌诊断中的应用。本文采用0.1-2太赫兹脉冲光谱对1例福尔马林固定口腔鳞状细胞癌(恶性)、成釉细胞瘤(良性)和牙源性角化囊肿进行了检测。据报道，恶性样品的吸收系数、折射率和消光系数比良性和囊肿样品高。用苏木精和伊红染色的显微图像验证了太赫兹的结果。结果表明，与良性和囊肿样品相比，恶性样品的太赫兹信号始终较高。这些结果表明，太赫兹信号通过消除水的影响来响应细胞密度。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.