α-Carboxylate Phosphabetains in Alkylation and Complexation Reactions

IF 0.4 Q4 MULTIDISCIPLINARY SCIENCES
Спектр Ямр, Спектр Яmp
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引用次数: 1

Abstract

Alkylation reactions of α-carboxylate phosphabetaines were carried out and studied to enhance the biological activity of previously synthesized carboxylate phosphabetaines. As a result of these reactions, the original structure was destroyed with the formation of quaternary salts of phosphonium triiodide. The structure and composition were confirmed by a complex of physical research methods, including NMR, IR spectroscopy, and elemental analysis. The bactericidal and antimycotic activity of the synthesized salts was assessed. The compounds showed activity similar to that of commercial drugs. The reactions of complexation of these structures were also investigated. In the reactions with nickel and copper chloride, complexes were isolated and characterized. The structure of the nickel complex was unambiguously confirmed by the data obtained with the help of single-crystal X-ray diffraction analysis.
α-羧酸磷脂在烷基化和络合反应中的应用
研究了α-羧酸型磷脂的烷基化反应,以提高已合成的羧酸型磷脂的生物活性。由于这些反应,原有的结构被破坏,形成了三碘化磷的季盐。结构和组成是由一个复杂的物理研究方法,包括核磁共振,红外光谱和元素分析证实。对合成盐的杀菌和抑菌活性进行了评价。这些化合物显示出与商业药物相似的活性。并对这些结构的络合反应进行了研究。在与镍和氯化铜的反应中,分离出配合物并进行了表征。用单晶x射线衍射分析得到的数据明确地证实了镍配合物的结构。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
0.70
自引率
0.00%
发文量
0
审稿时长
17 weeks
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