Centrosymmetric paddlewheel copper(II) complexes as potent intercalators: synthesis, crystal structure description and DNA-binding studies

IF 2.1 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Supramolecular Chemistry Pub Date : 2021-10-03 DOI:10.1080/10610278.2022.2137412

A. Mushtaq, M. Iqbal, Saqib Ali, M. Tahir

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引用次数: 0

Abstract

ABSTRACT Two copper(II) paddlewheel carboxylate complexes 1 and 2 of the general formula ACuL4CuA, where A is DMSO (1) and meta-bromopyridine (2) and L is meta-chlorophenyl acetate, have been synthesised, isolated quantitatively, crystallised and characterised using FTIR, UV-Visible spectroscopy, electrochemistry and XRD. FTIR spectra contained all the required peaks with the most prominent peaks those of carboxylate moiety indicating the bridging bidentate carboxylate binding mode. Electrochemistry yielded results typical of complexes containing Cu2+ centres. The structures were completely solved by XRD technique assigning square pyramidal geometry to each copper ion of the dinuclear complexes. The square base is formed by four oxygen atoms of the carboxylate moiety while the apical position is occupied by the fifth oxygen (of the DMSO molecule in 1) or nitrogen of the meta-bromopyridine in complex 2. The DNA-binding potency of the complexes was explored by viscometry, cyclic voltammetry, UV-Visible spectrophotometry and spectrofluorimetry. All these techniques provided coincident results and showed that the complexes bonded with DNA via an intercalative-binding mode. Additionally, these complexes were found to scavenge the free radical DPPH effectively. The complexes add interesting and valuable addition to the existing treasury on the copper paddlewheel complexes and their biological relevance. Graphical Abstract

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中心对称桨轮铜(II)配合物作为强插层剂:合成、晶体结构描述和dna结合研究

摘要合成了两种铜(II)桨轮羧酸配合物1和2，其通式为ACuL4CuA，其中A为DMSO(1)和间溴吡啶(2)，L为间氯苯乙酸酯，采用FTIR、uv -可见光谱、电化学和XRD进行了定量分离、结晶和表征。FTIR光谱包含所有要求的峰，羧酸部分的峰最突出，表明桥接双齿羧酸结合模式。电化学得到了典型的含Cu2+中心配合物的结果。用x射线衍射(XRD)技术对双核配合物的铜离子进行了方锥体结构分析。方基由羧酸部分的4个氧原子组成，而顶端位置由配合物2中邻溴吡啶分子的第5个氧原子或氮占据。通过黏度法、循环伏安法、紫外可见分光光度法和荧光光谱法研究了配合物的dna结合能力。所有这些技术都提供了一致的结果，表明复合物通过插入结合模式与DNA结合。此外，这些复合物还能有效清除自由基DPPH。这些配合物为铜桨轮配合物及其生物学相关性的现有宝库增加了有趣和有价值的补充。图形抽象

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来源期刊

Supramolecular Chemistry 化学-化学综合

CiteScore

3.60

自引率

3.00%

发文量

审稿时长

2.7 months

期刊介绍： Supramolecular Chemistry welcomes manuscripts from the fields and sub-disciplines related to supramolecular chemistry and non-covalent interactions. From host-guest chemistry, self-assembly and systems chemistry, through materials chemistry and biochemical systems, we interpret supramolecular chemistry in the broadest possible sense. Interdisciplinary manuscripts are particularly encouraged. Manuscript types include: high priority communications; full papers; reviews, and; Methods papers, techniques tutorials highlighting procedures and technologies that are important to the field. We aim to publish papers in a timely fashion and as soon as a paper has been accepted and typeset it will be published in electronic form on the Latest articles section of the website. The two most important review criteria are that the paper presents high-quality work that fits generally into the broad spectrum of activities in the supramolecular chemistry field. Under normal circumstances, Supramolecular Chemistry does not consider manuscripts that would be more suitable in a highly specialized journal. This includes, but is not limited to, those based mostly or exclusively on topics such as solid state/X-ray structures, computational chemistry, or electrochemistry. . The two most important review criteria are that the paper presents high-quality work that fits generally into the broad spectrum of activities in the supramolecular chemistry field.