On the balance of interaction modes in supramolecular complexes of a carboxylic acid host and alcohol guests. X-ray crystal structures of inclusion compounds with MeOH and EtOH

Abstract

Remarkable differences have been observed between the host–guest interaction modes in two closely related crystalline inclusion compounds [1·MeOH (1:1) and 1·EtOH(1:1)] of the same carboxylic host (1). The minor modification of the guest structure crucially affected the hydrogen bonding recognition pattern between given complementary groups, which demonstrates the sensitive balance of intermolecular interaction modes that must be controlled for successful crystal engineering and design of supramolecular compounds.