Poly(ethyleneglycol) in electrospray ionization (ESI) mass spectrometry

Abstract

Poly(ethyleneglycol) (PEG) substituted by various organic moities were analyzed by electrospray ionization (ESI) mass spectrometry in order to determine the best experimental protocol allowing reproducible, sensitive and informative spectra in the search of completely automated high throughput identification of libraries generated by the liquid-phase methodology. The nature of the eluent and of the PEG derivatization as well as the value of the sampling cone voltage were investigated by comparing the recorded oligomer distributions.