Gender and Psychotropic Poisoning in the USA

Aleena Vargas, George Ormseth, A. Seifi
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引用次数: 5

Abstract

Background: This study focuses on gender-based trends in psychotropic agent poisoning across a 17-year span. The goal of the study was to determine whether there are statistically significant differences in the characteristics of male and female hospital stays for psychotropic agent poisoning. Methods: We used the Healthcare Cost and Utilization Project (HCUP) national database to perform a retrospective cohort study analyzing trends for poisoning by psychotropic agents in males and females between 1997 and 2014. Results: Between 1997 and 2014, HCUP recorded a total of 1,368,649 psychotropic agent poisoning discharges. The overall number of discharges increased from 62,148 to 82,905 (P < 0.001). The average age at discharge increased from 37.36 to 40.85 years (P < 0.001). As the average length of stay increased from 2.3 to 3.2 days (P < 0.001), hospital charges increased from $6,357 to $27,892 (P < 0.001). Across the study period, the number of in-hospital deaths increased from 468 to 755 (P < 0.001). In each year of the study, both number of discharges and average age were found to be greater for females than for males (P < 0.001). Conclusions: Female discharges were consistently higher than male discharges, suggesting that female patients were more likely to experience psychotropic poisoning than male patients. This may possibly be due to a greater number of women being prescribed psychotropic medications, in concordance with higher rates of mood and anxiety disorders. Additionally, there exist notable differences in drug metabolism that should be considered to prevent overprescribing. J Neurol Res. 2020;10(6):220-225 doi: https://doi.org/10.14740/jnr640
美国的性别与精神药物中毒
背景:本研究关注17年来精神药物中毒的性别趋势。本研究的目的是确定精神药物中毒的男女住院特征是否有统计学上的显著差异。方法:利用卫生保健成本与利用项目(HCUP)国家数据库,对1997 - 2014年男性和女性精神药物中毒趋势进行回顾性队列研究。结果:1997 - 2014年,HCUP共记录精神药物中毒病例1368649例。出院总人数从62148例增加到82905例(P < 0.001)。平均出院年龄由37.36岁增加到40.85岁(P < 0.001)。由于平均住院时间从2.3天增加到3.2天(P < 0.001),住院费用从6 357美元增加到27 892美元(P < 0.001)。在整个研究期间,住院死亡人数从468人增加到755人(P < 0.001)。在研究的每一年,女性的出院次数和平均年龄都大于男性(P < 0.001)。结论:女性患者的出院率始终高于男性患者,提示女性患者比男性患者更容易发生精神药物中毒。这可能是由于更多的妇女服用精神药物,与较高的情绪和焦虑障碍率相一致。此外,药物代谢存在显著差异,应考虑防止过量用药。中华神经科学杂志,2020;10(6):220-225 doi: https://doi.org/10.14740/jnr640
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