Comparison of Psoriasis Area and Severity Index (PASI) Scores in Patients Treated with Oral Methotrexate and A Combination of Oral Methotrexate and Narrow Band-Ultraviolet B (NB-UVB) Phototherapy

Ervina Rosmarwati, N. Mulianto, Bobby Febrianto, Dita Eka Novriana, Siti Efrida Fiqnasyani
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Abstract

Background: Psoriasis Vulgaris is an autoimmune disease characterized by chronic skin inflammation and epidermal hyperplasia. Psoriasis Area Severity Index (PASI) score is one of the assessments to measure the psoriasis severity. Oral methotrexate is one of the effective therapies for psoriasis patients. Narrow Band-Ultraviolet B (NB-UVB) phototherapy is an adjunctive psoriasis therapy given concurrently with oral methotrexate. Purpose: Determine the difference in Psoriasis Area Severity Index (PASI) scores between Psoriasis Vulgaris patients treated with oral methotrexate and a combination of oral methotrexate and NB-UVB phototherapy. Methods: This observational analytic study was conducted at the Dermatology and Venereology Clinic, Dr. Moewardi General Hospital Surakarta. The patients received oral methotrexate and a combination of oral methotrexate and and Narrow Band-Ultraviolet B (NB-UVB) phototherapy. A retrospective study of medical records was conducted to determine the patient's PASI score before the therapies and 3 months after. All data were analyzed with the Shapiro Wilk normality test and the independent T-test. A p-value was <0.05, and it was considered significant. Result: The mean of decreased PASI scores in the oral methotrexate group was (6.00 +2.47) and (6.08 +2.17) in the combination therapy group. Based on the statistical test results from the 24 subjects, it was found that the PASI score decreased (p=0.931). Conclusion: There was no significant difference in the decrease in PASI between the oral methotrexate group and the combination therapy group. The mean reduction of PASI scores was more significant in the combination therapy than in the methotrexate group
口服甲氨蝶呤与口服甲氨蝶呤联合窄带紫外线B (NB-UVB)光疗治疗银屑病面积及严重程度指数(PASI)评分的比较
背景:寻常型牛皮癣是一种以慢性皮肤炎症和表皮增生为特征的自身免疫性疾病。银屑病严重程度指数(Psoriasis Area Severity Index, PASI)评分是衡量银屑病严重程度的指标之一。口服甲氨蝶呤是治疗银屑病的有效方法之一。窄带紫外线B (NB-UVB)光疗是一种辅助治疗银屑病同时给予口服甲氨蝶呤。目的:确定口服甲氨蝶呤与口服甲氨蝶呤联合NB-UVB光疗对寻常型银屑病患者银屑病区严重指数(PASI)评分的差异。方法:这项观察性分析研究在雅加达Moewardi综合医院皮肤病和性病诊所进行。患者接受口服甲氨蝶呤和口服甲氨蝶呤与窄带紫外线B (NB-UVB)光疗联合治疗。对医疗记录进行回顾性研究,以确定患者在治疗前和治疗后3个月的PASI评分。所有数据均采用Shapiro Wilk正态性检验和独立t检验进行分析。p值<0.05,认为显著。结果:口服甲氨蝶呤组PASI评分下降的平均值为(6.00 +2.47),联合治疗组PASI评分下降的平均值为(6.08 +2.17)。根据24名被试的统计检验结果,PASI得分下降(p=0.931)。结论:口服甲氨蝶呤组与联合治疗组在PASI降低方面无显著差异。与甲氨蝶呤组相比,联合治疗组PASI评分的平均降低更为显著
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