Computational modelling of Hedgehog signalling in liver regeneration

Q3 Pharmacology, Toxicology and Pharmaceutics

Drug Discovery Today: Disease Models Pub Date : 2016-12-01 DOI:10.1016/j.ddmod.2017.06.001

Madlen Matz-Soja

引用次数: 3

Abstract

Organ regeneration is a very complex process that includes not only the reconstruction of organ mass but also the reorganisation of homeostatic capabilities. This especially applies for the liver, which performs a variety of metabolic functions. In the last decade, morphogenic pathways such as the Wnt/β-Catenin and Hedgehog signalling pathways have been revealed to orchestrate liver regeneration as well as metabolism. Mathematical models have been successfully applied to liver regeneration, but these have not integrated the Hedgehog signalling pathway. In this review it is tried to compile features of Hh signalling in liver regeneration which can be integrated into liver regeneration modeling.

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肝脏再生中Hedgehog信号传导的计算模型

器官再生是一个非常复杂的过程，不仅包括器官质量的重建，也包括体内平衡能力的重组。这尤其适用于肝脏，它执行各种代谢功能。在过去的十年中，形态发生途径如Wnt/β-Catenin和Hedgehog信号通路已被发现协调肝脏再生和代谢。数学模型已经成功地应用于肝脏再生，但这些模型并没有整合刺猬信号通路。在这篇综述中，它试图汇编Hh信号在肝脏再生中的特征，可以整合到肝脏再生模型中。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Drug Discovery Today: Disease Models Pharmacology, Toxicology and Pharmaceutics-Drug Discovery

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期刊介绍： Drug Discovery Today: Disease Models discusses the non-human experimental models through which inference is drawn regarding the molecular aetiology and pathogenesis of human disease. It provides critical analysis and evaluation of which models can genuinely inform the research community about the direct process of human disease, those which may have value in basic toxicology, and those which are simply designed for effective expression and raw characterisation.