Analysis of the Clinical Effects of Clopidogrel in the Treatment of Unstable Angina and the Influence of Triacylglycerol and Total Cholesterol Levels

Abstract

Objective: To explore the clinical value of clopidogrel as the main treatment for patients with unstable angina. Methods: From January 2020 to December 2022, we assigned 50 cases to the control group (basic treatment) and 50 cases to the observation group (basic treatment with clopidogrel). The clinical data of both groups of patients were analyzed. Results: The total effective rate of the observation group was significantly higher than that of the control group after treatment (P < 0.05). Before treatment, there were no significant differences in the duration of angina pectoris and frequency of attacks between the two groups (P > 0.05); after treatment, the duration of angina pectoris and frequency of attacks in the observation group were significantly lower than those in the control group (P < 0.05). Before treatment, there were no significant differences in hemorheological indices, triacylglycerol (TG), total cholesterol (TC), and platelet aggregation rate between the two groups (P > 0.05); however, after treatment, they were significantly lower in the observation group than in the control group (P < 0.05). Before treatment, there was no significant difference in the scores of SF-36 between the two groups (P > 0.05); after treatment, the SF-36 score of the observation group was significantly higher than that of the control group (P < 0.05). Conclusion: Clopidogrel can promote the rehabilitation of patients with unstable angina during treatment. Compared with conventional basic treatment, it can reinforce the final therapeutic effect. In addition, our study showed that the duration of angina pectoris and the frequency of attacks were shortened after clopidogrel therapy and the treatment had an effect on improving patients’ hemorheological indices, TG, TC, and platelet aggregation rate. Clopidogrel therapy plays an important role in ensuring the quality of life of patients after recovery.