Antipsychotics With Different Chemical Structures Cause Different Degrees of Functional Impairments in the Primary Visual Cortex in a Murine Model: A Pilot Study.

IF 3.1 4区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemical Research in Chinese Universities Pub Date : 2021-12-01 DOI:10.5152/pcp.2021.20022

Si Gao, Xiaoyan Ma, Feng Ji, Ce Chen, Deguo Jiang, Yong Xu, Xueqin Song, Wenqiang Wang, Xiaodong Lin, Hongjun Tian, Chuanjun Zhuo, Xinwu Ye, Haiping Yu

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Abstract

Background: Antipsychotic medications can impair vision in patients with schizophrenia. However, little is known regarding the pharmacodynamics of antipsychotics in the primary visual cortex. We aimed to study the pharmacodynamics of antipsychotics in the visual cortex in a murine model.

Methods: We used an adapted 2-photon imaging technique to observe changes in calcium dynamics induced by 4 antipsychotics (olanzapine, risperidone, aripiprazole, and amisulpride) in the primary visual cortex of healthy and schizophrenic C57BL/6 mice. Visual function was further assessed by using a novel object recognition test.

Results: All 4 antipsychotics decreased calcium activity in the primary visual cortex and reduced visual recognition test scores in healthy and schizophrenic mice. The most potent drug was olanzapine, followed by risperidone, aripiprazole, and amisulpride. All drugs showed significant differences between groups.

Conclusion: Our pilot study demonstrated that antipsychotics impair visual cortical function. This finding underscores the importance of monitoring for visual adverse events in patients receiving antipsychotic medications to treat schizophrenia.

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在小鼠模型中，不同化学结构的抗精神病药物会对初级视觉皮层造成不同程度的功能损害：一项试验性研究

背景：抗精神病药物会损害精神分裂症患者的视力：抗精神病药物会损害精神分裂症患者的视力。然而，人们对抗精神病药物在初级视觉皮层中的药效学知之甚少。我们的目的是在小鼠模型中研究抗精神病药物在视觉皮层中的药效学：方法：我们使用一种改良的双光子成像技术来观察健康和精神分裂症C57BL/6小鼠的初级视皮层中4种抗精神病药（奥氮平、利培酮、阿立哌唑和阿米舒必利）诱导的钙动力学变化。通过新物体识别测试进一步评估视觉功能：结果：所有四种抗精神病药物都降低了健康小鼠和精神分裂症小鼠初级视觉皮层的钙活性，并降低了视觉识别测试得分。药效最强的药物是奥氮平，其次是利培酮、阿立哌唑和阿米舒必利。所有药物在组间均有明显差异：我们的试点研究表明，抗精神病药物会损害视觉皮层功能。结论：我们的试点研究表明，抗精神病药物会损害视觉皮层功能，这一发现强调了监测接受抗精神病药物治疗精神分裂症患者视觉不良事件的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Chemical Research in Chinese Universities 化学-化学综合

CiteScore

5.30

自引率

6.50%

发文量

152

审稿时长

3.0 months

期刊介绍： The journal publishes research articles, letters/communications and reviews written by faculty members, researchers and postgraduates in universities, colleges and research institutes all over China and overseas. It reports the latest and most creative results of important fundamental research in all aspects of chemistry and of developments with significant consequences across subdisciplines. Main research areas include (but are not limited to): Organic chemistry (synthesis, characterization, and application); Inorganic chemistry (bio-inorganic chemistry, inorganic material chemistry); Analytical chemistry (especially chemometrics and the application of instrumental analysis and spectroscopy); Physical chemistry (mechanisms, catalysis, thermodynamics and dynamics); Polymer chemistry and polymer physics (mechanisms, material, catalysis, thermodynamics and dynamics); Quantum chemistry (quantum mechanical theory, quantum partition function, quantum statistical mechanics); Biochemistry; Biochemical engineering; Medicinal chemistry; Nanoscience (nanochemistry, nanomaterials).