Andrey V. Samoshin, I. Dotsenko, Nataliya M. Samoshina, A. Franz, V. Samoshin
{"title":"Thio-β-D-glucosides: Synthesis and Evaluation as Glycosidase Inhibitors and Activators","authors":"Andrey V. Samoshin, I. Dotsenko, Nataliya M. Samoshina, A. Franz, V. Samoshin","doi":"10.1155/2014/941059","DOIUrl":null,"url":null,"abstract":"Structurally simple 1-thio-β-D-glucopyranosides were synthesized and tested as potential inhibitors toward several fungal glycosidases from Aspergillus oryzae and Penicillium canescens. Significant selective inhibition was observed for α- and β-glucosidases, while a weak to moderate activation for α- and β-galactosidases.","PeriodicalId":13788,"journal":{"name":"International Journal of Carbohydrate Chemistry","volume":"31 1","pages":"1-8"},"PeriodicalIF":0.0000,"publicationDate":"2014-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"6","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Carbohydrate Chemistry","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1155/2014/941059","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 6
Abstract
Structurally simple 1-thio-β-D-glucopyranosides were synthesized and tested as potential inhibitors toward several fungal glycosidases from Aspergillus oryzae and Penicillium canescens. Significant selective inhibition was observed for α- and β-glucosidases, while a weak to moderate activation for α- and β-galactosidases.