Santhosh Kumar Chinnaiyan , Mohan Raj Subramanian , S. Vinoth Kumar , Atul N. Chandu , Karthikeyan Deivasigamani
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引用次数: 16
Abstract
Rationale
Resistance against antibiotics of numerous bacteria is accumulating. Therefore, searches for innovative substances with antimicrobial activity have become an insistent necessity. Medicinal plants are recurrently used in popular medicine as remedies for many infectious diseases.
Aim
This study aimed to determine the in-vitro antimicrobial and anti-HIV activity of Canthium coromandelicum leaf extract against bacteria, fungi and viral component.
Methods
The plant extract screened for their antimicrobial activity against ten bacterial strains including Gram negative, Gram-positive bacteria, and six fungal strains using agar well diffusion, and microbroth dilution assays. The in-vitro anti-HIV assay was performed by reverse transcriptase (RT) and gp120 binding inhibition assay.
Results
The methanolic extract showed the broad spectrum antimicrobial activity. The minimum inhibitory concentration of 64, 124 μg/ml showed against Salmonella typhi and Candida albicans respectively. The methanolic extract exhibit highest inhibition on HIV reverse transcriptase 78.67 ± 0.13 and glycoprotein 120 binding 72.52 ± 0.13.
Conclusion
The overall results provide information for the possible use of C. coromandelicum leaf extract in the control of microbial and HIV infections.
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