Hydrogen and halogen bonds in drug-drug cocrystals of X-uracil (X = F, I) and lamivudine: extended quadruplex and layered assemblies

IF 2.1 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Supramolecular Chemistry Pub Date : 2021-12-02 DOI:10.1080/10610278.2022.2163644

Chang-Zhi Li, E. Keene, Celymar Ortiz-de León, Leonard R. MacGillivray

引用次数: 0

Abstract

ABSTRACT We report drug-drug cocrystals of the cytotoxic chemotherapy drugs 5-fluoro (5FU)/iodouracil (5IU) and the antiretroviral lamivudine (3TC). The cocrystal 2(5FU)·(3TC) is sustained by hydrogen bonds to generate a three-dimensional (3D) network while halogen bonds in the cocrystal (5IU)·(3TC) effectively disrupt hydrogen bonds to form layered assemblies. Graphical abstract

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X-尿嘧啶(X = F, I)和拉米夫定的药物-药物共晶体中的氢卤素键:扩展的四重键和层状组合

摘要:我们报道了细胞毒性化疗药物5-氟(5FU)/碘脲嘧啶(5IU)和抗逆转录病毒拉米夫定(3TC)的药物-药物共晶体。共晶2(5FU)·(3TC)由氢键维持形成三维(3D)网络，而共晶(5IU)·(3TC)中的卤素键有效地破坏氢键形成层状组合。图形抽象

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来源期刊

Supramolecular Chemistry 化学-化学综合

CiteScore

3.60

自引率

3.00%

发文量

审稿时长

2.7 months

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