Infectious diseases.

IARC scientific publications Pub Date : 2018-10-25 DOI:10.7326/0003-4819-97-5-804_1

B. Foxman

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引用次数: 1

Abstract

Molecular tools have enhanced our understanding of the epidemiology of infectious diseases by describing the transmission system, including identifying novel transmission modes and reservoirs, identifying characteristics of the infectious agent that lead to transmission and pathogenesis, identifying potential vaccine candidates and targets for therapeutics, and recognizing new infectious agents. Applications of molecular fingerprinting to public health practice have enhanced outbreak investigation by objectively confirming epidemiologic evidence, and distinguishing between time-space clusters and sporadic cases. Clinically, moleculartools are used to rapidly detect infectious agents and predict disease course. Integration of molecular tools into etiologic studies has identified infectious causes of chronic diseases, and characteristics of the agent and host that modify disease risk. The combination of molecular tools with epidemiologic methods provides essential information to guide clinical treatment, and to design and implement programmes to prevent and control infectious diseases. However, incorporating molecular tools into epidemiologic studies of infectious diseases impacts study design, conduct, and analysis.

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传染病。

分子工具通过描述传播系统，包括识别新的传播模式和宿主，识别导致传播和发病机制的感染因子的特征，识别潜在的候选疫苗和治疗靶点，以及识别新的感染因子，增强了我们对传染病流行病学的理解。分子指纹技术在公共卫生实践中的应用，通过客观确认流行病学证据，区分时空聚集性病例和零星病例，加强了疫情调查。在临床上，分子工具被用于快速检测感染因子和预测疾病进程。将分子工具整合到病原学研究中，已经确定了慢性疾病的感染原因，以及改变疾病风险的病原体和宿主的特征。分子工具与流行病学方法的结合为指导临床治疗以及设计和实施预防和控制传染病的方案提供了重要信息。然而，将分子工具纳入传染病流行病学研究会影响研究的设计、实施和分析。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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IARC scientific publications

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