Effects of Sevoflurane or Propofol on Immune Function in Patients Undergoing Hepatectomy

Journal of Anesthesia and Perioperative Medicine Pub Date : 2017-01-01 DOI:10.24015/JAPM.2017.0001

Gao-feng Hao, S. Jinchao, Zhang Jinmin, Jiao Ying-Fu, Lu Zhi-Jie, Tao Tian-Zhu, Weiqing Yu

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引用次数: 1

Abstract

Background: In this study, the effects of sevoflurane or propofol on immune function in patients undergoing partial hepatectomy were investigated during general anesthesia and after surgery.Methods: Seventy-two patients undergoing hepatectomy were randomized into sevoflurane group or propofol group. Sevoflurane or target-controlled infusion (TCI) of propofol was separately used to anesthesia induction and maintenance of two groups. Venous blood samples were taken before induction, 2 hours after anesthesia and 2 hours after surgery for measurement of the percentages of T lymphocyte (CD3+, CD4+, CD8+) and NK cells.Results: Compared with that before anesthesia induction, percentage change in CD3+ and CD4+ T cells to baseline was -0.7% and 3.8% in sevoflurane group, 10.2% and 20.2% in propofol group 2 hours after anesthesia (P=0.002 for CD3+ T cells and P=0.029 for CD4+ T cells ). Percentage change in NK cells was 17.6% in sevoflurane and -12.2% in propofol group 2 hours after anesthesia respectively (P=0.03). There was no significant difference in percentage change 2 hours after surgery of T cells and NK cells to baseline between two groups.Conclusions: Our study indicates that use of propofol during general anesthesia tend to increase the percentages of peripheral CD3+ and CD4+ cells, while sevoflurane increase the peripheral NK cells. Citation: Hao Gao, Jin-Chao Song, Jin-Min Zhang, Ying-Fu Jiao, Zhi-Jie Lu,Tian-Zhu Tao, et al. Effects of sevoflurane or propofol on immune function in patients undergoing hepatectomy. J Anesth Perioper Med 2017; 4: 1-6. doi: 10.24015/JAPM.2017.0001This is an open-access article, published by Evidence Based Communications (EBC). This work is licensed under the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium or format for any lawful purpose. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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七氟醚或异丙酚对肝切除术患者免疫功能的影响

背景:在本研究中，研究了七氟醚或异丙酚对肝部分切除术患者全身麻醉和术后免疫功能的影响。方法:将72例肝切除术患者随机分为七氟醚组和异丙酚组。两组分别采用七氟醚或异丙酚靶控输注(TCI)进行麻醉诱导和维持。分别于诱导前、麻醉后2小时和术后2小时取静脉血，测定T淋巴细胞(CD3+、CD4+、CD8+)和NK细胞的百分比。结果:与麻醉诱导前相比，麻醉后2 h，七氟醚组CD3+和CD4+ T细胞与基线的百分比变化分别为-0.7%和3.8%，异丙酚组为10.2%和20.2% (CD3+ T细胞P=0.002, CD4+ T细胞P=0.029)。麻醉后2 h，七氟醚组NK细胞变化百分比为17.6%，异丙酚组NK细胞变化百分比为-12.2% (P=0.03)。两组术后2小时T细胞、NK细胞与基线的百分率变化无显著差异。结论:我们的研究表明，全身麻醉时使用异丙酚倾向于增加外周血CD3+和CD4+细胞的百分比，而七氟醚倾向于增加外周血NK细胞的百分比。引用本文:高浩，宋金超，张金民，焦英富，卢志杰，陶天柱，等。七氟醚或异丙酚对肝切除术患者免疫功能的影响。中华外科杂志2017;4: 1 - 6。doi: 10.24015/ japm .2017.0001这是一篇开放获取的文章，由Evidence Based Communications (EBC)发表。本作品遵循知识共享署名4.0国际许可协议，允许以任何媒介或格式出于任何合法目的不受限制地使用、分发和复制。要查看此许可证的副本，请访问http://creativecommons.org/licenses/by/4.0/。

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Journal of Anesthesia and Perioperative Medicine

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