Effect of aging on spontaneous micronucleus frequencies in peripheral blood of nine mouse strains: the results of the 7th collaborative study organized by CSGMT/JEMS · MMS

Mutation Research/DNAging Pub Date : 1996-05-01 DOI:10.1016/S0921-8734(96)90011-9

Sei-ichi Sato , Masako Taketomi , Madoka Nakajima , Michiyo Kitazawa , Hiroyasu Shimada , Satoru Itoh , Miyuki Igarashi , Naohiko Higashikuni , Shizuyo Sotou , Yu F. Sasaki , Makoto Hayashi , Toshio Sofuni , Takafumi Higashiguchi , Shinji Nito , Yasushi Kondo , Sachiko Honda , Mikiko Hayashi , Yasuhiro Shinagawa , Eiichi Nakajima , Yoshie Oka , Koichi Tamai

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引用次数: 11

Abstract

The spontaneous frequencies of micronucleated reticulocytes (MNRETs) were examined monthly over the life spans of animals beloning to nine mouse strains for the 7th collaborative study organized by the CSGMT/JEMS · MMS. Both sexes of the BDF1 strain and females of the A/J strain showed a statistically significant increase ni mean spontaneous MNRET frequency in their last month of life, suggesting the possibility of strain-specific, age-dependent chromosomal instability. SAMP6/Tan, an accelerated senescence-prone strain, showed the same tendency, although it was not statistically significant. The other strains studied, ddY, CD-1, B6C3F1, SAMR1, and MS/Ae, did not show significant age-related differences in mean of MNRET frequencies. More extensive statistical analyses are underway, and the outcomes will be reported separately.

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衰老对9种小鼠外周血自发微核频率的影响:CSGMT/JEMS·MMS第七次合作研究结果

在CSGMT/JEMS·MMS组织的第7次合作研究中，我们每月检测9个小鼠品系的微核网状细胞(mnret)的自发频率。BDF1菌株的两性和A/J菌株的雌性在其生命的最后一个月的平均自发MNRET频率均有统计学意义的增加，这表明可能存在菌株特异性的、年龄依赖性的染色体不稳定性。加速衰老倾向菌株SAMP6/Tan也表现出同样的趋势，但没有统计学意义。其他菌株ddY、CD-1、B6C3F1、SAMR1和MS/Ae在MNRET平均频率上没有显着的年龄相关差异。更广泛的统计分析正在进行中，结果将单独报告。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Mutation Research/DNAging

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