Evaluation of the Potential Antioxidant Role of High-Density Lipoprotein-Cholesterol (HDL-C) in Patients with Ulcerative Colitis

Abstract

Background: Ulcerativecolitisisacommontypeof inflammatoryboweldisease(IBD).Theaimof thepresentstudywastoexamine therelationshipbetweenlipidprofile,especiallyhigh-densitylipoprotein(HDL),andmalondialdehyde(MDA)levelinpatientswith ulcerative colitis. Methods: In this study, 45 patients with ulcerative colitis were selected, 25 of whom were diagnosed with active disease and 20 were in clinical remission. Moreover, 45 healthy subjects were selected as the controls. The status of serum lipid profile and MDA level were measured via precise photometric methods. The obtained data were analyzed, using independent t-test and correlation coefficient test. P < 0.05 was considered statistically significant. Results: Theserumlevelof HDL-Cdecreased,whiletheserumlevelof MDAsignificantlyincreasedinpatientswithulcerativecolitis incomparisonwiththehealthycontrols(P< 0.05). NosignificantcorrelationwasobservedbetweentheMDAlevelandtriglyceride, cholesterol, and LDL-C levels in patients with ulcerative colitis. However, a significant inverse correlation was observed between HDL-C and MDA levels (r, -0.306; P < 0.05). Conclusions: TheinversecorrelationbetweenHDL-CandMDAlevelscanberegardedasanindicatorof theprotectiveroleof HDL-C againstlipidperoxidationinulcerativecolitis. Inpatientswithulcerativecolitis,theserumlevelof HDL-Cdecreasedincomparison with healthy subjects. Therefore, it is necessary to determine the HDL-C level in patients with ulcerative colitis.