Dissolution Modulating Mechanism of Flurbiprofen Solid Dispersions: Characterization, Physical Stability and in vivo Performance: Formulation Considerations and optimization study

Abstract

Present work studied interaction between Surelease, Urea, and Eudragit RL100 (RL) polymers with nonsteroidal anti-inflammatory drug FLP. Solid dispersions at different weight ratios were prepared by fusion (Method A) and coprecipitation (Method B). Characterization of solid dispersions (SDs) included elemental analysis, Fourier transform (FTIR), Differential scanning calorimetry (DSC), Powder-x-ray diffractometry (XRD), Scanning electron microscopy (SEM) as well as wettability study, angle of repose, aqueous solubility determination, in vitro and in vivo drug release. FTIR studies showed the stability FLP. DSC and XRD studies confirmed the amorphous state of FLP in its SDs. SEM showed the formation of effective SDs of FLP with polymers. Pre-formulation studies showed increased hydrophilicity but a non-significant increase in lipophilicity of the SDs. IDR value is only 0.03±0.001 mg/cm2-min. whereas wettability of solid dispersions was found to be controlled. Angle of repose shows good flowability characteristics. The dissolution rate of FLPSDs prepared by method A was significantly greater than that from method B. Method A with urea and RL provides slower and more gradual increase in dissolution rate than those of FLP, when polymer ratios were increased. TF20 possess longer duration of action compared to FLP.