The Efficacy of Botulinum Toxin in Cluster Headache: A Systematic Review.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2020-04-01 DOI:10.11607/ofph.2444

Brin Freund, Ivan S. Kotchetkov, Aruna S Rao

{"title":"The Efficacy of Botulinum Toxin in Cluster Headache: A Systematic Review.","authors":"Brin Freund, Ivan S. Kotchetkov, Aruna S Rao","doi":"10.11607/ofph.2444","DOIUrl":null,"url":null,"abstract":"AIMS\nTo conduct a systematic review of the literature on the use of botulinum toxin for the treatment of cluster headache.\n\n\nMETHODS\nA systematic review and data quality analysis were performed using PRISMA and GRADE guidelines, respectively. Inclusion and exclusion criteria were outlined prior to the search and aimed to select prospective studies that examined the use of botulinum toxin for the treatment of cluster headache.\n\n\nRESULTS\nThree studies resulted from the search that each included 10 to 17 subjects. All three demonstrated significant improvement in the frequency of headaches that occurred as quickly as 1 week following treatment. There was low-quality evidence that botulinum toxin was effective in reducing headache frequency and severity by at least 50%. Injections into the sphenopalatine ganglion may have a higher incidence of adverse events.\n\n\nCONCLUSION\nThis review summarizes the only prospectively collected efficacy and safety data regarding the use of botulinum toxin in cluster headache. Off-label use should be considered in certain cases. Further study is warranted to better characterize injection paradigms and patient selection, given the encouraging but limited data available.","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":null,"pages":null},"PeriodicalIF":16.4000,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"12","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Accounts of Chemical Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.11607/ofph.2444","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}

引用次数: 12

Abstract

AIMS To conduct a systematic review of the literature on the use of botulinum toxin for the treatment of cluster headache. METHODS A systematic review and data quality analysis were performed using PRISMA and GRADE guidelines, respectively. Inclusion and exclusion criteria were outlined prior to the search and aimed to select prospective studies that examined the use of botulinum toxin for the treatment of cluster headache. RESULTS Three studies resulted from the search that each included 10 to 17 subjects. All three demonstrated significant improvement in the frequency of headaches that occurred as quickly as 1 week following treatment. There was low-quality evidence that botulinum toxin was effective in reducing headache frequency and severity by at least 50%. Injections into the sphenopalatine ganglion may have a higher incidence of adverse events. CONCLUSION This review summarizes the only prospectively collected efficacy and safety data regarding the use of botulinum toxin in cluster headache. Off-label use should be considered in certain cases. Further study is warranted to better characterize injection paradigms and patient selection, given the encouraging but limited data available.

查看原文本刊更多论文

肉毒毒素治疗丛集性头痛的疗效:系统评价。

目的对有关肉毒杆菌毒素治疗丛集性头痛的文献进行系统综述。方法分别采用PRISMA和GRADE指南进行系统评价和数据质量分析。纳入和排除标准在检索之前进行了概述，旨在选择使用肉毒杆菌毒素治疗丛集性头痛的前瞻性研究。结果从搜索中得出三个研究，每个研究包括10到17个受试者。在治疗后1周内，这3例患者的头痛发生率均有显著改善。有低质量的证据表明，肉毒杆菌毒素在减少头痛频率和严重程度至少50%方面有效。注射到蝶腭神经节可能有较高的不良事件发生率。结论本综述总结了唯一前瞻性收集的有关肉毒毒素治疗丛集性头痛的疗效和安全性的资料。在某些情况下应考虑说明书外使用。鉴于令人鼓舞但有限的可用数据，有必要进一步研究以更好地表征注射模式和患者选择。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.