Antihyperlipidemic and antioxidant activities of Bruguiera cylindrinca (L)

Abstract

Background: Atheroclerosis is the major cause of morbidity and mortality world wide. The drugs used these days have some or other side effects. Aim: Therefore it is an urgent need to develop a safe and cheaper drugs for the society. We have planned this study to investigate lipid lowering and antioxidant activities of Bruguiera cylindrinca in triton and cholesterol fed rats. Materials and Methods: Different extract and fractions were collected from B. cylindrica. Two major compounds were isolated from there and have been tested for their lipid lowering activity along with increase in high density lipoprotein,cholesterol, compared with the cholesterol fed animals. Results: On chronic feeding of active fraction and pure compounds (at 100 mg / kg b.w.) for 30 days. The pure compounds isolated from the active fraction were found showing lipid lowering activity similar to the fraction. Conclusion: Structre modification of the two pure compounds isolated from the active fraction is required for further enhacement of biological activity.