Cyclohexannulated [5.3.1]propellanes as precursors to the ABC ring system of paclitaxel (taxolTM)

Abstract

Thermal or silver-ion induced electrocyclic ring-opening of Cyclohexannulated [5.3.1]propellanes such as 7 and 8 provides ABC ring analogues of paclitaxel (taxol) including compounds 10, 11 and 14.