{"title":"Healing Of Skin Warts with Ultradiluted Homeopathic Medicines- A Study in 200","authors":"S. Shraddhamayananda","doi":"10.15226/2378-1726/4/5/00172","DOIUrl":null,"url":null,"abstract":"Historically HPV (Chart 1) is known as the cause of common and anogenital warts (Palefsky, [9]) and it is an important fact that 60% of all types of HPV cause warts which are the benign neoplasms. Cancer transformation in HPV infection is mainly due to three major viral oncoproteins (E5, E6, and E7) which cause alteration of cell cycle regulation and telomere maintenance and block tumor suppressor pathways and apoptosis. HPV shows specific tropism toward the epithelial basal layer, containing adult epithelial stem cells and HPV binding receptors integrin α6. The E6/E7 oncoproteins control cytokine expression which alter cell proliferation and interferon expression. Expression of HPV viral proteins and viral integration promotes chromosomal anomalies and cellular immortalization (Pullos, et al. [10]). There are more than 200 different HPV types which have been identified and classified into 5 genera, α, β, γ, μ, and ν. Cell mediated immunity generally terminates non-oncogenic HPV infection within 2 years Abstract","PeriodicalId":15586,"journal":{"name":"Journal of Clinical Research","volume":"61 1","pages":"1-4"},"PeriodicalIF":0.0000,"publicationDate":"2017-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Clinical Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.15226/2378-1726/4/5/00172","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 3
Abstract
Historically HPV (Chart 1) is known as the cause of common and anogenital warts (Palefsky, [9]) and it is an important fact that 60% of all types of HPV cause warts which are the benign neoplasms. Cancer transformation in HPV infection is mainly due to three major viral oncoproteins (E5, E6, and E7) which cause alteration of cell cycle regulation and telomere maintenance and block tumor suppressor pathways and apoptosis. HPV shows specific tropism toward the epithelial basal layer, containing adult epithelial stem cells and HPV binding receptors integrin α6. The E6/E7 oncoproteins control cytokine expression which alter cell proliferation and interferon expression. Expression of HPV viral proteins and viral integration promotes chromosomal anomalies and cellular immortalization (Pullos, et al. [10]). There are more than 200 different HPV types which have been identified and classified into 5 genera, α, β, γ, μ, and ν. Cell mediated immunity generally terminates non-oncogenic HPV infection within 2 years Abstract