A comparison of the efficacy and rate of side-effects of mefenamic acid and naproxen in adult patients following elective tonsillectomy: A randomized double-blind study

Acute Pain Pub Date : 2008-12-01 DOI:10.1016/j.acpain.2008.07.003

G. Graf , M. Jelen , D. Jamnig , H. Schabus , W. Pipam , R. Likar

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引用次数: 7

Abstract

The aim of this study was to assess the efficacy and side-effects of mefenamic acid as compared to naproxen administered postoperatively to patients following elective tonsillectomy.

Methods

Fifty patients received either naproxen or mefenamic acid given postoperatively in a randomized fashion following elective tonsillectomy. General anaesthesia for the tonsillectomies was administered in a standardized fashion. Pain intensity was assessed postoperatively at rest and on exertion using the numeric rating scale (NRS) and analgesic consumption. The side-effects were also documented.

Results

Forty-one patients were included in the assessment. There were no significant differences with respect to the demographic data. After the 48th postoperative hour the NRS score demonstrated a significant difference in pain intensity at rest and on exertion in favour of the mefenamic acid group. There was no difference in the rate of side-effects between the two groups.

Conclusion

Mefenamic acid is a more effective analgesic than naproxen given postoperatively following elective tonsillectomies.

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甲氧胺酸和萘普生在成人选择性扁桃体切除术后的疗效和副反应率的比较:一项随机双盲研究

本研究的目的是评估甲氧胺酸与萘普生对选择性扁桃体切除术后患者的疗效和副作用。方法50例择期扁桃体切除术后随机给予萘普生或甲氧胺酸治疗。扁桃体切除术的全身麻醉以标准化的方式进行。采用数值评定量表(NRS)和镇痛药用量评估术后休息和运动时的疼痛强度。副作用也有记录。结果41例患者纳入评估。在人口统计数据方面没有显著差异。术后48小时后，NRS评分显示休息和运动时的疼痛强度有显著差异，甲胺酸组更有利。两组之间的副作用发生率没有差异。结论甲氧胺酸是选择性扁桃体切除术后较萘普生更有效的镇痛药。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Acute Pain

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