Extracellular matrix components remodeling and lung function parameters in experimental emphysema and allergic asthma: Differences among the mouse strains

Q3 Pharmacology, Toxicology and Pharmaceutics

Drug Discovery Today: Disease Models Pub Date : 2019-06-01 DOI:10.1016/j.ddmod.2019.04.001

Milena Vasconcellos Oliveira, Pedro Leme Silva, Patricia Rieken Macedo Rocco

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引用次数: 1

Abstract

Mice are frequently used in experimental models of respiratory diseases due to their ease of manipulation, genetic homogeneity within inbred populations, and possibility of standardizing environmental exposures. However, it is well established that genetic strain variations in mice may exist, which imply changes in extracellular matrix (ECM) composition and degree of ECM remodeling, with potential for major impacts on respiratory mechanics. The lung ECM is mainly composed of fibrous proteins (collagen and elastin), glycoproteins (fibronectin and laminin), proteoglycans (PGs), and glycosaminoglycans (GAGs). The functions of many ECM components are well described, but their role in the pathogenesis of respiratory diseases, such as emphysema and asthma, requires further elucidation. The aim of this review is to address ECM composition, function, and remodeling as well as demonstrate its relationship with the mechanical profile of the lung in different strains of mice subjected to experimental emphysema and allergic asthma.

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实验性肺气肿和变应性哮喘小鼠株间细胞外基质成分重构和肺功能参数的差异

由于小鼠易于操作、近亲繁殖群体内的遗传同质性以及标准化环境暴露的可能性，它们经常被用于呼吸系统疾病的实验模型。然而，已经确定小鼠可能存在遗传变异，这意味着细胞外基质(ECM)组成和ECM重塑程度的变化，可能对呼吸力学产生重大影响。肺ECM主要由纤维蛋白(胶原蛋白和弹性蛋白)、糖蛋白(纤连蛋白和层粘连蛋白)、蛋白聚糖(pg)和糖胺聚糖(GAGs)组成。许多ECM成分的功能已经被很好地描述，但它们在呼吸系统疾病(如肺气肿和哮喘)发病机制中的作用还需要进一步阐明。本综述的目的是探讨实验性肺气肿和过敏性哮喘小鼠不同品系中ECM的组成、功能和重塑，以及其与肺力学特征的关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Drug Discovery Today: Disease Models Pharmacology, Toxicology and Pharmaceutics-Drug Discovery

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期刊介绍： Drug Discovery Today: Disease Models discusses the non-human experimental models through which inference is drawn regarding the molecular aetiology and pathogenesis of human disease. It provides critical analysis and evaluation of which models can genuinely inform the research community about the direct process of human disease, those which may have value in basic toxicology, and those which are simply designed for effective expression and raw characterisation.