POPULATION DYNAMICS OF NORMAL AND CANCER CELLS UNDER RADIOTHERAPY

Musiliu Folarin Farayola, S. Shafie, Fuaada Mohd Siam
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Abstract

The use of the improved cancer treatment model predicted the population changes in the normal and cancer cells during radiotherapy. The simulated radiation doses are 15 Gy, 18 Gy, 20 Gy and 24 Gy administered 5 times for each dose. The population of the cancer cells reduced from 40 % of the carrying capacity to 10.72%, 23.25 %, 1.61 % and 3.72 % of the carrying capacity for the respective doses. The population of the normal cells reduced from 70% of the carrying capacity to 65.50%, 62.48%, 68.49% and 67.59% of the carrying capacity for the respective doses. During the no treatment stage (0 Gy), the model predicted an increase in the population of cancer cells and a decrease in the population of normal cells.
放射治疗下正常细胞和癌细胞的种群动态
利用改进的肿瘤治疗模型预测放疗期间正常细胞和癌细胞的种群变化。模拟辐射剂量分别为15 Gy、18 Gy、20 Gy和24 Gy,每剂量给药5次。在不同剂量下,肿瘤细胞的数量分别从40%减少到10.72%、23.25%、1.61%和3.72%。在不同剂量下,正常细胞的数量分别从70%降至65.50%、62.48%、68.49%和67.59%。在无治疗阶段(0 Gy),该模型预测癌细胞数量增加,正常细胞数量减少。
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