Synthesis, Molecular Docking Studies and Antibacterial Evaluation of Baylis-Hillman Adducts of Coumarin and Pyran Derivatives Using Ionic Liquid under Microwave Irradiation

Abstract

The Baylis-Hillman adducts 3(a-e) and 6(a-g) were prepared by the reaction of appropriate aldehydes with alkenes in presence of catalytic amount of urotropine with ionic liquids under microwave irradiation. Structures of the newly synthesized compounds were characterized by spectral studies. The antibacterial studies of Baylis-Hilmann compounds for analysis of the structural requirements for antibacterial activity using VLife MDS 3.5 has been carried out.