Antimicrobial Properties of Phenolic Extracts against Nosocomial Drug Resistant Organisms

Abstract

Nosocomial Multi Drug resistance microbial infection is a global concern nowadays. Due to its multi-drug resistant nature, treatment with conventional antibiotics does not assure desired clinical outcomes. Therefore, there is a need to find new compounds and/or alternative methods to get arsenal against the pathogen. Combination therapies using conventional antibiotics and phytochemicals fulfill both requirements [1]. A variety of essential oils have been screened for their antimicrobial activity [15]. The antimicrobial activity of plant-derived essential oils is the basis of many applications, especially in food preservation, aromatherapy and medicine. This present study demonstrates the efficacy of phenolic-phytochemical extract combinations from pine, coconut and oatmeal colloidal solution against multidrug resistant organisms such as Staphylococcus aureus (ATCC 43300), Pseudomonas aeruginosa (ATCC 27853) and Candida albicans (ATCC 10231). The efficacy of the phytochemical combinations against these microbes were measured by estimating the inhibitory zone as produced by antibiotic sensitivity disc diffusion method on Mueller-Hinton agar. These results can be used as a support in doing further quantitative analysis in prevention and treatment of the common infectious diseases that is caused by these organisms [4].