Effects of Ferula Rigidula plant extract on hyperglycemia, hyperlipidemia and pancreatic tissue oxidative stress in rats with experimental diabetes

Abstract

Ferula rigidula (FR) is one of the herbs used in traditional treatments. The aim of this study is to investigate the effects of this plant, which is used in traditional treatment, on insulin secretion, blood glucose level, lipid profile and some oxidative stress parameters in diabetes.In addition, studies on the total phenolic and flavonoid content of the plant extract, the determination of antioxidant activity by DPPH and CUPRAC method, and the lethal dose of FR were also performed. For the diabetes study, 49 male Wistar albino rats were used. Rats were divided into seven groups as control, diabetes, diabetes+ FR (250mg/kg), diabetes+ FR (500 mg/kg), diabetes+glibenclamide (5 mg/kg), FR (250 mg/kg), FR (500 mg/kg) group. According to the diabetes group, fasting blood glucose levels in the diabetes+FR 500 mg/kg group decreased. Cholesterol and HDL levels decreased in the diabetes+FR 250-500 mg/kg and diabetes+glibenclamide groups. MDA level decreased in diabetes+FR 250-500 mg/kg and diabetes+glibenclamide groups but it was determined that GSH level and CAT, GSH-Px, SOD enzyme activities increased. The positive effects of FR on some parameters that change in diabetes and examined in this study are explained.