Synthesis and Self-assembly Behaviors of the ABC Miktoarm Star Terpolymer

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2014-06-20 DOI:10.3724/SP.J.1105.2014.13396

Yang Bai, Xiaodong Fan, W. Tian, Hao Yao, W. Fan, Tingting Liu, J. Dang, Xiuzhong Zhu

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引用次数: 0

Abstract

The ABC miktoarm star terpolymer MPEG-PTHF (-PDMA) was synthesized by the combination of click chemistry, atom transfer radical polymerization (ATRP) and cationic ring opening polymerization (CROP). A block copolymer of poly(ethylene glycol) (PEG) and poly(N,N-dimethylaminoethyl methacrylate) (PDMA) which bears an azido at diblock junction (MPEG-N3 (-PDMA)) was first prepared by atom transfer radical polymerization. Then, an alkynyl-terminated narrow distributed polytetrahydrofuran (PTHF-Alk) was synthesized as another building block via cationic ring opening polymerization. The well-defined ABC miktoarm star shaped terpolymer was afforded by clicking MPEG-N, (-PDMA) onto the chain end of PTHF-Alk. The structure of the star terpolymer was characterized by the FTIR,NMR and SEC/MALLS. The self-assembly behavior of the polymer were investigated by dynamic light scattering (DLS) and transmission electron microscopy (TEM). This star shaped terpolymer consists of a hydrophobic PTHF chain, a hydrophiphilic PEG chain and another stimuli-responsive PDMA chain. It can self-assemble into micelles with different sizes and morphologies at various pH values, such as 5. 0,7. 4 and 9. 5. The micellar size also exhibits temperature-dependence at pH 7. 4 and 9. 5. The variation of size and morphology of the micelles with the solution pH and temperature is ascribed to the pH- and thermo-responsive properties of the PDMA block.

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ABC型密臂星形共聚物的合成及其自组装行为

采用点击化学、原子转移自由基聚合(ATRP)和阳离子开环聚合(CROP)相结合的方法合成了ABC型密臂星型共聚物MPEG-PTHF (-PDMA)。采用原子转移自由基聚合的方法，首次制备了在双嵌段连接处带有叠氮基团的聚乙二醇(PEG)和聚(N,N-二甲氨基甲基丙烯酸乙酯)(PDMA)嵌段共聚物(MPEG-N3 (-PDMA))。然后，通过阳离子开环聚合，合成了端烷基窄分布聚四氢呋喃(PTHF-Alk)。将MPEG-N， (-PDMA)点击到PTHF-Alk的链端，得到了定义明确的ABC型密臂星形三元共聚物。通过FTIR、NMR和SEC/ mall对该星型三元共聚物的结构进行了表征。采用动态光散射(DLS)和透射电子显微镜(TEM)研究了聚合物的自组装行为。该星形三元共聚物由疏水的PTHF链、亲水的PEG链和另一个刺激响应的PDMA链组成。它可以在不同的pH值下自组装成不同大小和形态的胶束，如5。0, 7。4和9。5. 在pH值为7时，胶束大小也表现出温度依赖性。4和9。5. 胶束的大小和形态随溶液pH和温度的变化归因于PDMA块的pH和热响应特性。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.