Simultaneous Derivative Spectrophotometric Determination of Lornoxicam and Paracetamol in Tablet Dosage Forms

Abstract

Lornoxicam and Paracetamol in combined dosage forms (Tablets). The zero crossing point of Paracetamol (247.42 nm) has been selected for the quantification of Lornoxicam whereas the zero crossing point of Lornoxicam (233.28 nm) has been selected for the quantification of Paracetamol from the first order derivative spectrum observed in borate buffer. The method obeys Beer-Lambert’s law over the concentration range 5-50 µg/ml for Lornoxicam and 5-60 µg/ml for Paracetamol. The proposed method was validated and can be used for the analysis of tablet dosage forms containing Lornoxicam and Paracetamol. K ey words: Lornoxicam, Paracetamol, Spectrophotometry, Derivative spectroscopy, Validation.