Curative effect of synchronous radiochemotherapy in medium-term and advanced cervical carcinoma

实用妇产科杂志 Pub Date : 2007-01-01 DOI:10.3760/CMA.J.ISSN.1006-9801.2008.06.012

F. Ying

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引用次数: 0

Abstract

Objective To investigate the curative effect of synchronous radio-chemotherapy in medium-term and advanced cervical carcinoma. Methods 168 cases of medium-term and advanced cervical carcinoma were selected. The treatment group(grout A) included 84 pathologically verified cases of stage Ⅱ～Ⅳ cervical carcinoma. Each patient was given DDP with hydration at the dose of 40 mg/m2 intravenously.The treatment cycle was performed once every week for 3--4 circles. Radiotherapy was given at the same time. 60Co was used for external radiation with a total dose of 50 Gy, 192 Ir afterloading unit was used for brachytherapy at the dose of 7 Gy per week at point A with a total dose of 42 Gy. The control group (group B)included 84 cases of cervical carcinoma at the same stage in the corresponding period who received radiotherapy only.Short-term effect ,2-year survival rate and complications were observed. Results Effective rate was 92.85 %(78/84) in group A and 79.76 %(67/84) in group B respectively 3 months after radiotherapy, showing a significant difference(χ2 =6.10,P <0.05). 2-year survival rate was higher in group A (83.95 %) than in Group B(60.98 %) (χ2 =9.4,P<0.05). Local recurrent and distant metastasis were lower in Group A than Group B. In group A, there were tolerable bone marrow inhibition and reaction of digestive tract. Conclusion Synchronous radiotherapy and chemotherapy can remarkably improve the survival rate of medium-term and advanced cervical carcinoma. The application of DDP is effective and safe,and its side effect can be accepted by patients, but the long-term effect needs further observation. Key words: Uterine cervical neoplasms; Combination chemotherapy; Radiotherapy; Combined modality therapy

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中晚期宫颈癌同步放化疗的疗效观察

目的探讨同步放化疗治疗中晚期宫颈癌的疗效。方法对168例中晚期宫颈癌患者进行回顾性分析。治疗组(A组)84例经病理证实为Ⅱ~Ⅳ期宫颈癌。每例患者静脉给予DDP并水化，剂量为40mg /m2。治疗周期为每周1次，共3- 4个周期。同时给予放疗。60Co用于总剂量为50 Gy的外照射，192 Ir后载单位用于a点近距离放疗，剂量为7 Gy /周，总剂量为42 Gy。对照组(B组)84例同期同一阶段仅行放疗的宫颈癌患者。观察两组近期疗效、2年生存率及并发症。结果放疗后3个月，A组有效率为92.85% (78/84)，B组有效率为79.76%(67/84)，差异有统计学意义(χ2 =6.10,P <0.05)。A组患者2年生存率(83.95%)高于B组(60.98%)(χ2 =9.4,P<0.05)。A组局部复发和远处转移发生率低于b组。A组骨髓抑制及消化道反应耐受。结论同步放化疗可显著提高中晚期宫颈癌的生存率。DDP的应用有效、安全，其副作用可为患者所接受，但远期效果有待进一步观察。关键词:子宫颈肿瘤;结合化疗;放射治疗;综合疗法

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来源期刊

实用妇产科杂志

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发文量

9946

期刊介绍： The Journal of Practical Obstetrics and Gynecology was founded in October 1985. It is a professional journal of obstetrics and gynecology that is publicly distributed at home and abroad and is supervised by the Health Commission of Sichuan Province, sponsored by the Medical and Health Service Guidance Center of Sichuan Province, and co-organized by the Sichuan Medical Association, Sichuan Medical Association, and Sichuan Nursing Association. The magazine is mainly aimed at scientific research and clinical workers in the fields of obstetrics and gynecology, women's health, reproductive health, etc., aiming to solve various scientific research and clinical practical problems in obstetrics and gynecology and reproductive health work, and improve the level of medical care. This magazine is based on clinical practice and adheres to practicality. It is very different from similar magazines and has a strong professional guidance role and practical value for obstetricians and gynecologists and reproductive health workers. The journal has an editorial committee composed of more than 200 famous obstetricians and gynecologists and well-known scholars at home and abroad to provide technical guidance for the journal.