S. Hadi, E. K. Winarno, H. Winarno, Khairunnisa Berawi, T. Suhartati, Y. Yandri, W. Simanjuntak
{"title":"Synthesis, characterization and in vitro activity study of some organotin(IV) carboxylates against leukemia cancer cell, L-1210","authors":"S. Hadi, E. K. Winarno, H. Winarno, Khairunnisa Berawi, T. Suhartati, Y. Yandri, W. Simanjuntak","doi":"10.1515/psr-2022-0303","DOIUrl":null,"url":null,"abstract":"Abstract This paper presents successful resynthesizing of several dibutyl-, diphenyl-, and triphenyltin(IV) carboxylate compounds, and their activity against leukemia cancer cell, L-1210. The compounds were synthesized by reacting the dibutyltin(IV) oxide (DBTO) (1), diphenyltin(IV) oxide (DPTO) (3), and triphenyltin(IV) hydroxide (TPTOH) (5) with 3-hydroxybenzoic acid (3-HHBz). Prior to cancer activity tests, the compounds were characterized by UV–Vis, FT-IR, NMR (both 1H NMR and 13C NMR), and microanalysis to determine elemental composition of the samples. The anticancer tests revealed that triphenyltin(IV) 3-hydroxybenzoate (TPTHBz) (6) displayed significantly higher activity than those exhibited by dibutyltin(IV) di(3-hydroxybenzoate) (DBTHBz) (2) and diphenyltin(IV) di(3-hydroxybenzoate) (DPTHBz) (4).","PeriodicalId":20156,"journal":{"name":"Physical Sciences Reviews","volume":"10 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2023-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Physical Sciences Reviews","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1515/psr-2022-0303","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Physics and Astronomy","Score":null,"Total":0}
引用次数: 1
Abstract
Abstract This paper presents successful resynthesizing of several dibutyl-, diphenyl-, and triphenyltin(IV) carboxylate compounds, and their activity against leukemia cancer cell, L-1210. The compounds were synthesized by reacting the dibutyltin(IV) oxide (DBTO) (1), diphenyltin(IV) oxide (DPTO) (3), and triphenyltin(IV) hydroxide (TPTOH) (5) with 3-hydroxybenzoic acid (3-HHBz). Prior to cancer activity tests, the compounds were characterized by UV–Vis, FT-IR, NMR (both 1H NMR and 13C NMR), and microanalysis to determine elemental composition of the samples. The anticancer tests revealed that triphenyltin(IV) 3-hydroxybenzoate (TPTHBz) (6) displayed significantly higher activity than those exhibited by dibutyltin(IV) di(3-hydroxybenzoate) (DBTHBz) (2) and diphenyltin(IV) di(3-hydroxybenzoate) (DPTHBz) (4).
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