Association of Hypoalbuminaemia with the Angiographic Severity of Coronary Artery Disease in Patients with Acute Coronary Syndrome

University Heart Journal Pub Date : 2022-01-31 DOI:10.3329/uhj.v18i1.57879

Jubair Mahmud Parvez, Md. Afzalur Rahman, A. Islam, M. Aziz, A. Mamun, M. Arefin, M. Azam

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Abstract

Introduction: Serum albumin as a biomarker of coronary artery disease (CAD) severity and mortality in patients with acute coronary syndrome (ACS) is presently a subject of growing interest. Evidences accumulated from the studies suggest a possible association between serum albumin and severity of CAD. Aim of the study: The aim of this study was to find the association between serum albumin level and severity of CAD in patients of ACS. Methods: The present cross-sectional analytical study was carried out in the Department of Cardiology, National Institute of Cardiovascular Diseases (NICVD), Dhaka, Bangladesh, over a period of 1 year from July 2017 to June 2018. A total of 104 ACS patients undergoing coronary angiogram in the above-mentioned hospital during the index hospitalization within the specified time-frame were included in the study. Result: None of the demographic characteristics and traditional risk factors for CAD except age was found to be associated with severity of CAD. Friesinger Score was significantly higher in patients with low serum albumin than that in patients with normal serum albumin (8.84 ± 3.71 vs. 6.38 ± 3.02, p<0.001). Leman Score was also significantly higher in in the former group than that in latter group (12.48 ± 8.44 vs. 8.50 ± 4.94 mm, p = 0.004).The risk of having severe CAD in patients with low serum albumin was 5.46(95% CI = 2.141 – 13.925) (p < 0.001) times higher in terms of Friesinger score and 2.58(95% CI = 1.097 – 6.083) (p = 0.03) times higher in terms of Leaman score than that in patients with normal serum albumin. Spearman’s correlation revealed that the two variables serum albumin and Friesinger score, exhibit a significantly inverse correlation (r = -0.323, p = 0.001). Serum albumin demonstrated a significantly inverse correlation with Leaman score (r = -0.254, p = 0.009). Conclusion: The study concluded that serum albumin concentration was significantly associated with the severity of coronary artery disease with low serum albumin carrying at least two-fold higher risk of having severe CAD, as measured by the Friesinger and Leaman score, in patients with ACS. University Heart Journal 2022; 18(1): 44-49

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急性冠状动脉综合征患者低白蛋白血症与冠状动脉疾病血管造影严重程度的关系

简介:血清白蛋白作为急性冠脉综合征(ACS)患者冠状动脉疾病(CAD)严重程度和死亡率的生物标志物，目前越来越受到关注。从研究中积累的证据表明血清白蛋白与冠心病严重程度之间可能存在关联。研究目的:本研究的目的是发现ACS患者血清白蛋白水平与冠心病严重程度之间的关系。方法:本横断面分析研究在孟加拉国达卡国家心血管疾病研究所(NICVD)心内科进行，为期1年(2017年7月至2018年6月)。本研究共纳入104例指标住院时间内在上述医院行冠脉造影的ACS患者。结果:除年龄外，没有发现冠心病的人口统计学特征和传统危险因素与冠心病的严重程度相关。血清白蛋白低组的fresinger评分显著高于血清白蛋白正常组(8.84±3.71∶6.38±3.02,p<0.001)。前者的Leman评分也显著高于后者(12.48±8.44 mm比8.50±4.94 mm, p = 0.004)。低血清白蛋白患者发生严重冠心病的风险是正常血清白蛋白患者的5.46(95% CI = 2.141 ~ 13.925)倍(p < 0.001)， Leaman评分是正常血清白蛋白患者的2.58(95% CI = 1.097 ~ 6.083)倍(p = 0.03)。Spearman相关分析显示血清白蛋白与Friesinger评分呈显著负相关(r = -0.323, p = 0.001)。血清白蛋白与Leaman评分呈显著负相关(r = -0.254, p = 0.009)。结论:该研究得出血清白蛋白浓度与冠状动脉疾病的严重程度显著相关，在ACS患者中，通过Friesinger和Leaman评分测量，低血清白蛋白携带的严重CAD风险至少高出两倍。大学心脏杂志2022;18 (1): 44-49

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University Heart Journal

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