Design and Fabrication of 3D Printed Bioresorbable Nerve Guide Conduit (NGC) for Peripheral Nerve Repair

Ankita Sharma, Chhavi Teotia, Pooja Bhati, M. Soni
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Abstract

In this study, 3D printing technology is utilized for the fabrication of designer structure bioresorbable Polylactic acid (PLA) NGCs for peripheral nerve regeneration. The designer structure of the NGCs is designed using solid works software. The bioresorbable PLA NGCs are printed using an extrusion-based 3D printer. PLA thread of 1.75 mm diameter is employed for the fabrication of 6±0.5 mm internal diameter and 35±10 mm long NGCs. The conduits were tested for the mechanical properties, surface properties such as surface wettability of the conduits were evaluated by measuring the water contact angle of the de-ionized water droplet deposited on the conduit surface. Fourier Transform Infrared Spectroscopy is used for the conduits surface chemistry study. Differential scanning Calorimetry (DSC) and Scanning Electron Microscopy (SEM) are used for the thermal and morphological characterization.
外周神经修复用3D打印生物可吸收神经导管的设计与制造
在本研究中,利用3D打印技术制造设计结构的生物可吸收聚乳酸(PLA) NGCs用于周围神经再生。利用solid works软件设计了NGCs的设计结构。生物可吸收PLA NGCs是使用基于挤压的3D打印机打印的。采用1.75 mm直径的聚乳酸线制作内径为6±0.5 mm、长为35±10 mm的NGCs。测试了管道的力学性能,并通过测量沉积在管道表面的去离子水滴的水接触角来评价管道的表面性能,如表面润湿性。利用傅里叶变换红外光谱对管道表面化学进行了研究。差示扫描量热法(DSC)和扫描电子显微镜(SEM)用于热学和形态学表征。
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