A simple kinetic method for the assay of nalidixic acid in formulations

Abstract

A simple selective kinetic method for the assay of nalidixic acid in solid state and pharmaceutical preparations is described. The reaction of nalidixic acid with persulfate in alkaline medium was carried out at 75°C. The correlation coefficient was found to be 1.0000. The activation parameters and the factor of the linear least square equation were calculated. The proposed method is suitable to determine nalidixic acid in the range 10–120 μg/ml.