Testing the adequacy of a simple theoretical model of dehydration optical clearing of collagen bundles: OCT measurements

IF 0.9 4区工程技术 Q3 Engineering

Quantum Electronics Pub Date : 2022-01-01 DOI:10.1070/QEL17965

O. A. Zyuryukina, M. E. Shvachkina, V. Kochubey, Y. Sinichkin, D. Yakovlev

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Abstract

Using optical coherence tomography, the scattering coefficients of collagen bundles are estimated at different levels of tissue hydration. We test the validity of a simple theoretical model of dehydration changes in the optical characteristics of a collagen bundle, which is considered as a system of parallel cylinders that model the collagen fibrils forming the bundle. The characteristics of scattering by individual scatterers are calculated using the Mie theory. To take into account the cooperative effects caused by the close packing of the scatterers, use is made of the standard packing function for a system of identical cylinders. The theoretical model also relies on a certain empirical law of changes in the hydration level of fibrils with a change in the water content in the tissue, which predetermines changes in the diameter and refractive index of fibrils during dehydration and rehydration of the tissue. It is shown that the theoretical estimates obtained using this model are in good agreement with the experimental data, which makes it possible to consider this model as reliable.

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检验胶原束脱水光学清除的简单理论模型的充分性:OCT测量

利用光学相干断层扫描，胶原束的散射系数估计在不同水平的组织水化。我们测试了一个简单的理论模型的有效性脱水变化的光学特性的胶原蛋白束，这被认为是一个平行的圆柱体系统，模拟胶原蛋白原纤维形成束。利用米氏理论计算了单个散射体的散射特性。为了考虑分散体紧密堆积所引起的协同效应，对相同圆柱体系统使用标准堆积函数。该理论模型还依赖于原纤维水化水平随组织含水量变化的一定经验规律，该规律预先决定了组织脱水和再水化过程中原纤维直径和折射率的变化。结果表明，利用该模型得到的理论估计与实验数据吻合较好，可以认为该模型是可靠的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Quantum Electronics 工程技术-工程：电子与电气

CiteScore

3.00

自引率

11.10%

发文量

审稿时长

3-6 weeks

期刊介绍： Quantum Electronics covers the following principal headings Letters Lasers Active Media Interaction of Laser Radiation with Matter Laser Plasma Nonlinear Optical Phenomena Nanotechnologies Quantum Electronic Devices Optical Processing of Information Fiber and Integrated Optics Laser Applications in Technology and Metrology, Biology and Medicine.