Preparation, Structural Characterization and Biological Activities of Curcumin-Metal(II)-L-3,4-dihydroxyphenylalanin (L-dopa) complexes

Hala M. Salh, T. AL-Noor
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Abstract

In the present work, a first-row divalent d-transition metal obtained from curcumin(Curc)  and L-3,4-dihydroxyphenylalanin(L-dopa)have been synthesized which their complexes and characterized by  C.H.N, conductance, spectral methods: FT-IR, Ultra–Visible. Magneto-chemical measurements, molar conductance ΛM (1×10−3 mol/L in DMSO):36- 0.84 ohm-1.cm2.mol-1 (non-electrolyte). The data shows that the complexes have the structure [M((II))-(Curc)-(L-dopa)] system. Electronic and magnetic data suggest an octahedral geometry for all complexes in which the (L-dopa) and curcumin act as bidentate ligands. Curcumin coordinated to the metal ions M (II) through the lone pair of electrons of oxygen in 2(C=O) groups. The (L-dopa) coordinated to M (II) as a mono negative bidentate ligand through the oxygen atom of the carboxylate and the (N), atom of the (-NH2) groups.    The general formula  was given for the prepared mixed ligand complexes as [M (Cur)(L-dopa)2 ].  M= Mn  (II), Fe (II),Co(II),Ni(II),Cu (II), Zn(II), Cd(II) and Hg(II).The ligands and their metal complexes were screened for their antimicrobial activity klebsiella pneumonie,and  Staphylococcus aureus, and Candida albicans. Metal chelates showed very good antimicrobial activity than their parent curcumin-and (L- dopa).     We have given the general formula for the prepared mixed ligand complexes as [M (Cur)(L-dopa)2].M= Mn  (II), Fe (II),Co(II)  ,Ni(II),Cu (II), Zn(II), Cd(II) and Hg(II).The ligands and their metal complexes were screened for their antimicrobial activity klebsiella pneumonie,and  Staphylococcus aureus, and Candida albicans. Metal chelates show very good antimicrobial activity than their parent Curcumin-and (L- dopa).
姜黄素-金属(II)- l -3,4-二羟基苯丙氨酸(L-dopa)配合物的制备、结构表征及生物活性
本文以姜黄素(Curc)和l -3,4-二羟基苯丙氨酸(L-dopa)为原料合成了一种第一排二价d-过渡金属,并通过电化学、电导、红外光谱、超可见光等方法对其进行了表征。磁化学测量,摩尔电导ΛM (1×10−3 mol/L的DMSO):36- 0.84欧姆-1 cm2。mol-1(非电解质)。数据表明,配合物具有[M((II))-(Curc)-(L-dopa)]体系结构。电子和磁数据表明,所有配合物的八面体几何形状,其中(左旋多巴)和姜黄素作为双齿配体。姜黄素通过氧的孤对电子在2(C=O)基团中与金属离子M (II)配位。(L-dopa)通过羧酸盐的氧原子和(-NH2)基团的(N)原子与M (II)配位为单负双齿配体。给出了所制备的混合配体配合物的通式为[M (Cur)(L-dopa)2]。M =锰(II)、铁(II),公司(II)、镍(II)、铜(II)、锌(II)、Cd (II)和Hg (II)。对这些配体及其金属配合物进行了抑菌活性筛选,检测其对肺炎克雷伯菌、金黄色葡萄球菌和白色念珠菌的抑菌活性。金属螯合物具有较好的抗菌活性,其亲本姜黄素和左旋多巴具有较好的抗菌活性。我们给出了所制备的混合配体配合物的通式为[M (Cur)(L-dopa)2]。M =锰(II)、铁(II),公司(II)、镍(II)、铜(II)、锌(II)、Cd (II)和Hg (II)。对这些配体及其金属配合物进行了抑菌活性筛选,检测其对肺炎克雷伯菌、金黄色葡萄球菌和白色念珠菌的抑菌活性。金属螯合物比其母体姜黄素和左旋多巴具有更好的抗菌活性。
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