ОПЫТ УСПЕШНОГО ПРИМЕНЕНИЯ ЭТАНЕРЦЕПТА У ПАЦИЕНТКИ С ПОЛИАРТИКУЛЯРНЫМ ВАРИАНТОМ ЮВЕНИЛЬНОГО ИДИОПАТИЧЕСКОГО АРТРИТА С ОБЗОРОМ ПРЕДИКТОРОВ ХОРОШЕГО ОТВЕТА НА ПРОВОДИМУЮ ТЕРАПИЮ

А. В. Карасёва, Екатерина Иосифовна Алексеева, Т. М. Дворяковская
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Abstract

The  article  presents  a case  of  polyarticular  juvenile  idiopathic  arthritis  resistant  to  methotrexate  therapy  and  nonsteroidal  antiinflammatory drugs.  The child was prescribed  a tumor necrosis  factor   inhibitor etanercept  at a dose  of 0.4 mg/kg body weight2 times/week. The treatment  with etanercept  induced remission of the disease, ensured the function restoration  in the joints. The predictors  of a good response  to etanercept  were the younger  age, the short  course  of the disease,  the use of a small number of immunosuppressants  before prescription of etanercept, the absence of concomitant use of glucocorticosteroids,  and the absence of uveitis.
患者成功使用异位性视网膜炎的经验,对治疗的前导反应良好的青少年特发性关节炎进行了审查。
本文报告一例多关节幼年特发性关节炎对甲氨蝶呤治疗和非甾体类抗炎药的抵抗。给患儿开肿瘤坏死因子抑制剂依那西普,剂量为0.4 mg/kg体重2次/周。依那西普治疗可使病情缓解,保证关节功能恢复。对依那西普有良好反应的预测因素是年龄较小,病程短,在处方依那西普之前使用少量免疫抑制剂,没有同时使用糖皮质激素,没有葡萄膜炎。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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