Cytotoxic activity of some Tanzanian medicinal plants.

The East and Central African Journal of Pharmaceutical Sciences Pub Date : 2006-11-01 DOI:10.4314/ECAJPS.V8I2.9723

D. Runyoro, A. Kamuhabwa, O. Ngassapa, P. Witte

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引用次数: 6

Abstract

Thirty-three aqueous methanolic extracts obtained from thirty plant species, belonging to seventeen families were screened for cytotoxic activity against HeLa (Human cervical carcinoma) cells. The ability of the extracts (10 g/ml and 1 g/ml) to inhibit proliferation of HeLa cells was determined using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide (MTT) dye reduction assay. Extracts from roots of Agathisanthemum bojeri, Synaptolepis kirkii and Zanha africana and the leaf extract of Physalis peruviana at a concentration of 10 µg/ml inhibited cell proliferation by 58.3 %, 68.1 %, 75.7 % and 91.8 %, respectively. The remaining 29 extracts exhibited no pronounced cytotoxic activity at the tested concentrations. It is worth investigating the four extracts, which showed pronounced cytotoxic activity so as to isolate and identify the compounds responsible for cytotoxic activity. Keywords : cytotoxic plants, Tanzanian medicinal plants, Agathisanthemum bojeri, Synaptolepis kirkii, Zanha africana, Physalis peruviana The East and Central African Journal of Pharmaceutical Sciences Vol. 8(2) 2005: 35-39

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坦桑尼亚一些药用植物的细胞毒活性。

从17科30种植物中提取33种甲醇水提物，对人宫颈癌细胞进行了细胞毒活性筛选。采用3-(4,5-二甲基噻唑-2-基)-2,5-二苯基溴化四唑(MTT)染料还原法测定提取物(10 g/ml和1 g/ml)抑制HeLa细胞增殖的能力。bojeri Agathisanthemum bojeri、Synaptolepis kirkii和Zanha africana根提取物和Physalis peruviana叶提取物浓度为10µg/ml时，对细胞增殖的抑制作用分别为58.3%、68.1%、75.7%和91.8%。其余29个提取物在测试浓度下没有明显的细胞毒活性。这四种提取物具有明显的细胞毒活性，值得进一步研究，以分离和鉴定具有细胞毒活性的化合物。关键词:细胞毒植物，坦桑尼亚药用植物，波jeri Agathisanthemum bojeri, Synaptolepis kirkii, Zanha africana, Physalis peruviana .东非和中非药学杂志Vol. 8(2) 2005: 35-39

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The East and Central African Journal of Pharmaceutical Sciences

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