The Effect of High-Dose Simvastatin Therapy on Patients with Acute Cerebral Infarction

Xiaozhu Liu, Huankun Liang, Kangyan Li, Jiali Li, Lai-qing Li, Licheng Zhang
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Abstract

Cerebrovascular disease (CVD) accounts for the major cause of morbidity and mortality in industrialized countries. However, effects of high-dose simvastatin therapy on patients with acute cerebral infarction still unclear. In this study, the clinical efficacy of high-dose simvastatin on patients with cerebral infarction was investigated. A total of 180 patients with acute cerebral infarction were randomized divided into control group (n=60), high-dose simvastatin (HDS) group (n=60) and low-dose simvastatin (LDS) group (n=60). Control group, HDS group and LDS group received conventional treatment, conventional treatment together with simvastatin 80 mg/d and conventional treatment as well as simvastatin 40 mg/d respectively for 3 months. Biochemical indices, neurological deficit and plaque thickness and volume were assessed and recorded after treatment. After simvastatin treatment, the plasma levels of Triglyceride, Total cholesterol, Low-density lipoprotein were significantly decreased in HDS group and LDS group, and HDS were significantly increased in HDS group and LDS group. Also, simvastatin decreased levels of IL-6 and TNF-α, two major inflammatory factors in plasma. Furthermore, improved neurological deficit were found in simvastatin treatment groups. In addition, simvastatin treatment also improved plaque states include plaque thickness and volume in HDS group and LDS group. Therefore, simvastatin could improve acute cerebral infarction and high-dose of simvastatin treatment was better than low -dose of simvastatin treatment.
大剂量辛伐他汀治疗急性脑梗死的疗效观察
脑血管病(CVD)是工业化国家发病率和死亡率的主要原因。然而,大剂量辛伐他汀治疗急性脑梗死的效果尚不清楚。本研究探讨大剂量辛伐他汀治疗脑梗死患者的临床疗效。180例急性脑梗死患者随机分为对照组(n=60)、高剂量辛伐他汀组(n=60)和低剂量辛伐他汀组(n=60)。对照组、HDS组、LDS组分别给予常规治疗、常规治疗联合辛伐他汀80 mg/d、常规治疗联合辛伐他汀40 mg/d,疗程3个月。治疗后观察生化指标、神经功能缺损、斑块厚度和体积。辛伐他汀治疗后,HDS组和LDS组血浆甘油三酯、总胆固醇、低密度脂蛋白水平均显著降低,HDS组和LDS组血浆HDS水平均显著升高。此外,辛伐他汀降低血浆中两种主要炎症因子IL-6和TNF-α的水平。此外,辛伐他汀治疗组的神经功能缺损得到改善。此外,辛伐他汀治疗还改善了HDS组和LDS组的斑块状态,包括斑块厚度和体积。因此,辛伐他汀可改善急性脑梗死,且高剂量辛伐他汀治疗优于低剂量辛伐他汀治疗。
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