Characterization of Neuronal Differentiation and Activity in Human-Induced Pluripotent Neural Stem Cells

A. Biddinger
{"title":"Characterization of Neuronal Differentiation and Activity in Human-Induced Pluripotent Neural Stem Cells","authors":"A. Biddinger","doi":"10.7771/2158-4052.1451","DOIUrl":null,"url":null,"abstract":"Traumatic brain injury (TBI) is one of the leading causes of death and disability in the United States, with more than 1.7 million people seeking medical care for TBI annually. Although there are currently no eff ective clinical treatments for TBI, preclinical treatments using neural stem cells (NSCs) have shown promising results to promote tissue neuroprotection and recovery post-injury. This study aims to analyze how NSCs diff erentiate into neural networks and seeks to characterize their corresponding activity level to help improve preclinical TBI treatments. Based upon past studies, we hypothesized that NSCs would diff erentiate into mature neurons within two weeks, but would have a delayed functional activity response of 1–2 months.","PeriodicalId":30386,"journal":{"name":"Journal of Purdue Undergraduate Research","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2020-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Purdue Undergraduate Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.7771/2158-4052.1451","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Traumatic brain injury (TBI) is one of the leading causes of death and disability in the United States, with more than 1.7 million people seeking medical care for TBI annually. Although there are currently no eff ective clinical treatments for TBI, preclinical treatments using neural stem cells (NSCs) have shown promising results to promote tissue neuroprotection and recovery post-injury. This study aims to analyze how NSCs diff erentiate into neural networks and seeks to characterize their corresponding activity level to help improve preclinical TBI treatments. Based upon past studies, we hypothesized that NSCs would diff erentiate into mature neurons within two weeks, but would have a delayed functional activity response of 1–2 months.
人诱导的多能神经干细胞的神经元分化和活性的表征
在美国,创伤性脑损伤(TBI)是导致死亡和残疾的主要原因之一,每年有超过170万人因TBI寻求医疗护理。虽然目前还没有有效的临床治疗方法,但使用神经干细胞(NSCs)进行临床前治疗在促进组织神经保护和损伤后恢复方面已经显示出有希望的结果。本研究旨在分析NSCs如何分化为神经网络,并试图表征其相应的活动水平,以帮助改善临床前TBI治疗。基于以往的研究,我们假设NSCs会在两周内分化为成熟的神经元,但会延迟1-2个月的功能活动反应。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
41
审稿时长
22 weeks
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信