PRO-INFLAMMATORY CYTOKINES IL-4 AND IL-13 IN CHILDREN WITH "SECRETOR" AND "NON-SECRETOR" STATUS OF H ANTIGEN DURING FOOD ALLERGY

Abstract

Analysis of peculiarities of production of inflammatory cytokines IL-4 and IL-13 in children with approved diagnosis "food allergy" with "secretor" and "non-secretor" H-antigen status was carried out. "Non-secretor" children were shown to have 1.7 times higher content of a Th2 inflammation marker, IL-4, in blood serum than children with "secretor" status. IL-13 content was also elevated, although not so significantly. In children with "non-secretor" status, higher level of pro-inflammatory cytokines correlated with more severe progression of allergic inflammation, which makes determination of H antigen in the saliva of children and their mothers a promising non-invasive prognostic marker of progression of allergic inflammation in children with food allergy.