Hepatic apolipoprotein A-I, C-III and E mRNA expressions in human parenchymal liver diseases

Abstract

In order to understand the mechanism underlying in dyslipoproteinemia accompanied with liver diseases, levels in apolipoproteins A-I, C-III and E mRNA expressions in various human parenchymal liver diseases were assessed by Northen blot analysis. The mRNA expressions were significantly decreased in liver cirrhosis and acute hepatitis as compared with controls and were correlated with serum albumin levels. This finding indicates that liver biosynthesis of these apolipoproteins is suppressed in parenchymal human liver disease. This could be one of the mechanisms causing the dyslipoproteinemia in the liver diseases. This is the first study to show decreased apolipoprotein gene expression in human parenchymal liver diseases.