Continuous-selective intra-arterial injection of antibiotics for osteoradionecrosis of the mandible

Asian Journal of Oral and Maxillofacial Surgery Pub Date : 2010-08-01 DOI:10.1016/j.ajoms.2009.11.007

Masashi Shiiba , Yosuke Sakamoto , Toru Tsurumi , Ryuji Namba , Masakazu Akiba , Ken Shimada , Kenshi Kawasaki , Atsushi Kasamatsu , Kanae Ono , Katsunori Ogawara , Katsuhiro Uzawa , Hideki Tanzawa

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Abstract

Objective

This study was performed to evaluate the usefulness of continuous-selective intra-arterial injection of antibiotics via the superior thyroid artery for osteoradionecrosis of the mandible.

Patients and methods

Three osteoradionecrosis cases were treated with this innovative drug delivery system. Totals of 7200 mg, 7810 mg and 6960 mg of clindamycin (CLDM) were administered in cases 1, 2 and 3, respectively. Patients also received conventional intravenous cefozopran hydrochloride (CZOP) or ceftazidime (CAZ) or moxifloxacin (MFLX) and hyperbaric oxygen therapy (HBO).

Results

Both clinical findings and laboratory data improved immediately after these treatments in these cases.

Conclusion

The present study indicates that continuous-selective antibiotic injection via the superior thyroid artery might be an additional treatment option if performed in combination with conventional approaches in the refractory cases.

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持续选择性动脉注射抗生素治疗下颌骨放射性骨坏死

目的探讨经甲状腺上动脉持续选择性动脉内注射抗生素治疗下颌骨放射性骨坏死的疗效。患者与方法应用该新型给药系统治疗3例放射性骨坏死。在病例1、2和3中，克林霉素(CLDM)的总剂量分别为7200 mg、7810 mg和6960 mg。患者还接受常规静脉注射盐酸头孢唑普兰(CZOP)或头孢他啶(CAZ)或莫西沙星(MFLX)和高压氧治疗(HBO)。结果这些病例的临床表现和实验室数据在治疗后立即得到改善。结论经甲状腺上动脉持续选择性注射抗生素可作为治疗顽固性甲状腺炎的一种补充方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Asian Journal of Oral and Maxillofacial Surgery

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