Overview of Heat Shock Proteins (HSPs) in Prokaryotes

N. Aljohani, J. Fletcher, H. E. El Shafey, S. Ghanem, S. A. Kabli, M. Morsi, Rami H Aljohani
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Abstract

Cellular defense mechanisms are the most primitive expression of a family of polypeptides called heat shocks or stress proteins (HSPs). Some of these HSPs are present in unstressed cells and play an essential role in polypeptide piling and translocation through membranes. Thus, (MC) were named. A variety of stresses, including hyperthermia, oxygen radicals, heavy metals, ethanol, and amino acid analogs, are expressed in HSPs. In clinically essential cases, including ischemia/reperfusion and circulatory and hemorrhagic shocks, the reaction to the heat shock is induced. All the above stresses have in common that they disrupt the tertiary protein structure and adversely affect the metabolism of the cells. Pre-handling of cells with moderate tension, enough to induce his expression, offers protection against subsequent insults. It is a "stress tolerance" coined phenomenon caused by the resolubilization of proteins denatured during stress. Furthermore, the second stress in stress-tolerant cells and species stabilizes or repairs the cellular structures (microfilaments and centrosomes) and processes (transcription, splicing, and translation). There is a large body of evidence to demonstrate that. Much research indicates that HSPs play an immediate role in stabilizing these incidents. As a natural mechanism for organ defense in dangerous environments and operations and in the fight against pathogens, HSPs have the inherent capacity to defend cells. This “stress tolerance” refers to the resolubilization of proteins that were denatured during stress. Besides, these are strengthened during stressful times and are resilient organisms. There is significant research saying that hypertension is involved in major cardiovascular diseases. HSPs can potentially enhance human recovery and combat pathogen infection
原核生物热休克蛋白(HSPs)研究综述
细胞防御机制是称为热休克或应激蛋白(HSPs)的多肽家族的最原始表达。其中一些热休克蛋白存在于非应激细胞中,并在多肽堆积和通过膜转运中发挥重要作用。因此,(MC)被命名。热休克蛋白表达多种应激,包括高温、氧自由基、重金属、乙醇和氨基酸类似物。在临床必要的情况下,包括缺血/再灌注、循环和失血性休克,对热休克的反应是诱导的。上述应激的共同之处是破坏三级蛋白结构,对细胞代谢产生不利影响。预先处理适度紧张的细胞,足以诱导他的表达,提供了对后续侮辱的保护。这是一种“应激耐受性”现象,是由应激过程中变性蛋白质的溶解引起的。此外,在耐应力细胞和物种中,第二种胁迫稳定或修复细胞结构(微丝和中心体)和过程(转录、剪接和翻译)。有大量的证据可以证明这一点。许多研究表明,高敏感人群在稳定这些事件中起着直接的作用。热休克蛋白作为器官在危险环境和操作以及对抗病原体时的天然防御机制,具有保护细胞的内在能力。这种“抗逆性”是指在压力下变性的蛋白质的再溶解性。此外,这些在压力时期得到加强,是有弹性的生物体。有重要的研究表明高血压与主要的心血管疾病有关。热休克蛋白可以潜在地促进人体恢复和对抗病原体感染
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