{"title":"Synthesis of Some New 2-Mercapto/Hydrizino 5, 6, 7, 8 - Tetrahydro Quinazoline Derivatives as In-Vitro Anthelimentic Agents","authors":"P. Srikumar, T. Lakshmi, K. Sekhar","doi":"10.15228/2013.V03.I04.P02","DOIUrl":null,"url":null,"abstract":"A new series of substituted 5, 6, 7, 8 tetrahydro quinazoline derivative has been synthesized from a mixture of methyl/ethylacetoacetate with different substituted aromatic/ hetero aromatic aldehydes. Then treated with aminoguanidines / thiourea afforded 2-hydrizino substituted 5, 6, 7, 8-tetrahydro quinazoline (D1-8)/ 2-mercapto substituted 5, 6, 7, 8-tetrahydro quinazoline derivatives (E1-8). The structures of newly synthesized compounds were confirmed by spectral data (IR, H 1","PeriodicalId":19815,"journal":{"name":"Pakistan Journal of Chemistry","volume":"11 1","pages":"150-155"},"PeriodicalIF":0.0000,"publicationDate":"2013-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pakistan Journal of Chemistry","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.15228/2013.V03.I04.P02","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
A new series of substituted 5, 6, 7, 8 tetrahydro quinazoline derivative has been synthesized from a mixture of methyl/ethylacetoacetate with different substituted aromatic/ hetero aromatic aldehydes. Then treated with aminoguanidines / thiourea afforded 2-hydrizino substituted 5, 6, 7, 8-tetrahydro quinazoline (D1-8)/ 2-mercapto substituted 5, 6, 7, 8-tetrahydro quinazoline derivatives (E1-8). The structures of newly synthesized compounds were confirmed by spectral data (IR, H 1
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