Nurse-led training programme on knowledge about sexual violence among adolescent females in selected secondary schools, Abeokuta South local government area, Ogun state

Global Journal of Pure and Applied Sciences Pub Date : 2021-06-24 DOI:10.4314/GJPAS.V27I2.15

I. Bassey, Etido Fidelis Udo, S. O. Adesite

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引用次数: 2

Abstract

Bryophyllum pinnatum is an important enthnomedicinal plant. The study assessed the effect of crude aqueous leaves extract of Bryophyllum pinnatum (CALEBP) on fasting plasma glucose (FPG), antioxidant status, lipid profile, liver and renal function indices in albino rats. The rats were housed under standard laboratory conditions (12h light: 12h dark photoperiod), 23± 2 oC and were given rat pellets and tap water ad libitum. Twenty four rats weighing 190-232g were randomized into four groups (A-D) of six rats each. Group A (control) received normal feed and water only. Groups B, C and D received orally 180, 360 and 540 mg/kg body weight respectively of CALEBP for 28 days. Serum aminotransferases, alkaline phosphatase (ALP), superoxide dismutase, catalase, FPG, lipid profile, urea, creatinine, bilirubin, proteins, malondialdehyde, glutathione (GSH) and total antioxidant capacity (TAC) and electrolytes were assessed by standard methods. Data were analyzed using one-way analysis of variance and p<0.05 was considered statistically significant. Groups C and D had significantly lower FPG (p = 0.030; p = 0.01) and higher ALP (p = 0.01; p = 0.001) compared to the controls. Group D had significantly lower creatinine (p = 0.03) and K+ (p = 0.02) compared to control. Group B, C and D had significantly lower GSH (p = 0.020, p = 0.000 and p = 0.000) while group B had significantly higher TAC (p = 0.04) compared to the controls. Dosage of extracts correlated positively with ALP (r = 0.705, p = 0.000) and negatively with FPG (r = -0.603, p = 0.002), K+ (r = -0.563, p = 0.004), creatinine (r = -0.464, p = 0.022) and GSH (r = -0.786, p = 0.000). Bryophyllum pinnatum aqueous leaves extract could lower blood glucose, potassium and creatinine levels and may increase ALP activity and GSH depletion in high doses. Keywords: Bryophyllum pinnatum, aqueous leaf extract, dosage, effect assessment, Albino rats

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在奥贡州阿贝奥库塔南部地方政府地区选定的中学中，由护士领导的关于青春期女性性暴力知识的培训方案

苔藓是一种重要的民族药用植物。本研究评价了青叶粗水提物(CALEBP)对白化大鼠空腹血糖(FPG)、抗氧化能力、血脂及肝肾功能指标的影响。将大鼠置于标准实验室条件下(光照12h:暗光照12h)，温度23±2℃，随机给予大鼠颗粒和自来水。取体重190 ~ 232g大鼠24只，随机分为4组(A-D)，每组6只。A组(对照组)仅饲喂正常饲料和水。B、C、D组分别口服CALEBP 180、360、540 mg/kg体重，疗程28 D。采用标准方法测定血清转氨酶、碱性磷酸酶(ALP)、超氧化物歧化酶、过氧化氢酶、FPG、血脂、尿素、肌酐、胆红素、蛋白质、丙二醛、谷胱甘肽(GSH)、总抗氧化能力(TAC)和电解质。资料采用单因素方差分析，p<0.05为差异有统计学意义。C、D组FPG显著降低(p = 0.030;p = 0.01)和较高的ALP (p = 0.01;P = 0.001)。与对照组相比，D组肌酐(p = 0.03)和K+ (p = 0.02)明显降低。与对照组相比，B、C、D组GSH显著降低(p = 0.020, p = 0.000, p = 0.000)，而B组TAC显著升高(p = 0.04)。提取物用量与ALP (r = 0.705, p = 0.000)呈正相关，与FPG (r = -0.603, p = 0.002)、K+ (r = -0.563, p = 0.004)、肌酐(r = -0.464, p = 0.022)、GSH (r = -0.786, p = 0.000)呈负相关。苔藓叶水提物在大剂量下可降低血糖、钾和肌酐水平，增加ALP活性和GSH消耗。关键词:青叶，水提物，剂量，效果评价，白化大鼠

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Global Journal of Pure and Applied Sciences

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